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Series GSE181526 Query DataSets for GSE181526
Status Public on Nov 01, 2023
Title Single cell analysis of meningeal ectopic lymphoid tissue and lumbar lymph nodes in a spontaneous EAE model
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Objective: To investigate how similar meningeal ectopic lymhpoid tissue (mELT) is to secondary lymphoid tissues and find unique features of mELT that could allow therapeutic targetting of mELT specifically. Methods: We utilized a spontaneous chronic experimental autoimmune encephalomyelitis (EAE) model of mice with mutant T and B cell receptors specific for myelin oligodendrocyte glycoprotein (MOG), which develop meningeal inflammatory infiltrates resembling those described in Multiple Sclerosis (MS). We identified differences in cell composition and gene expression between mELT and lumbar lymph nodes using single cell sequencing.
Overall design single cell gene expression and B cell receptor sequences of meningeal ectopic lymphoid tissue and lumbar lymph nodes in 3 Thx2D2 mice
Contributor(s) Lepennetier G, Lehmann-Horn K, Diddens J, Pfaller M, Brand RM
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Submission date Aug 05, 2021
Last update date Nov 01, 2023
Contact name Gildas Lepennetier
Organization name Klinikum Rechts der Isar
Department Neurology
Street address Ismaninger Stra├če 22
City Munich
ZIP/Postal code 81675
Country Germany
Platforms (2)
GPL16417 Illumina MiSeq (Mus musculus)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (16)
GSM5504566 GEX of Z3_E21_mELT
GSM5504567 GEX of Z3_E21_LN
GSM5504568 GEX of Z3_E72_mELT
BioProject PRJNA752357
SRA SRP331235

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE181526_RAW.tar 152.0 Mb (http)(custom) TAR (of CSV, MTX, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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