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| Status |
Public on Jul 05, 2022 |
| Title |
Non-equilibrium pronucleus histones require gametal factor Lsm1 induced major satellite RNA decay |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
The development of a multicellular organism with various organs and tissues is a complex but highly concerted process, in which cells acquire different identities through exquisite spatiotemporal regulations called cell fate decision. Here, we Lsm1 targets non-coding major satellite RNAs in mouse zygote, which is required for the non-equilibrium epigenetic modification, especially H3K9me3 establishment during early embryo development.
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| Overall design |
We performed RNAseq experiment on mouse zygotes with and without Lsm1 knockdown. We also performed RIP-seq on FLAG-Tagged LSM1, using NO-Tagged LSM1 as control.
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| Contributor(s) |
Zhu J |
| Citation(s) |
36810573 |
| |
| Submission date |
Jul 06, 2021 |
| Last update date |
Mar 10, 2023 |
| Contact name |
Jiang Zhu |
| E-mail(s) |
zhujiang860918@yahoo.com
|
| Organization name |
Tongji University
|
| Street address |
1239 Siping Road
|
| City |
Shanghai |
| ZIP/Postal code |
200092 |
| Country |
China |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA744199 |
| SRA |
SRP327180 |
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