|
| Status |
Public on Jan 25, 2022 |
| Title |
Heme-activated Nrf2 signaling skews fate trajectories of bone marrow cells from dendritic cells towards macrophages |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This SuperSeries is composed of the SubSeries listed below.
|
| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
35031770 |
| |
| Submission date |
Jul 02, 2021 |
| Last update date |
Jan 26, 2022 |
| Contact name |
Raphael Matthias Buzzi |
| E-mail(s) |
raphael.buzzi@usz.ch
|
| Organization name |
Universitätsspital and University of Zurich
|
| Department |
Division of Internal Medicine
|
| Street address |
Rämistrasse 100
|
| City |
Zürich |
| ZIP/Postal code |
8091 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (8)
|
| GSM5416209 |
GM-CSF BM-cultures from Nrf2-/- or wild-type littermates stimulated with heme or the selective Nrf2 activator ML-334 |
| GSM5416210 |
GM-CSF BM cultures treated with vehicle control (albumin) |
| GSM5416211 |
GM-CSF BM cultures treated with heme |
| GSM5416214 |
Multiplexed BM-derived cell culture experiment |
| GSM5416215 |
single cell suspension negatively enriched for DCs from a spleen of a wild-type mouse |
| GSM5416216 |
single cell suspension negatively enriched for DCs from a spleen of a SCD mouse |
| GSM5416217 |
single cell suspension positively enriched for macrophages using F4/80 magnetic beads from a spleen of a wild-type mouse |
| GSM5416218 |
single cell suspension positively enriched for macrophages using F4/80 magnetic beads from a spleen of a SCD mouse |
|
| This SuperSeries is composed of the following SubSeries:
|
| GSE179359 |
Heme-Nrf2 signaling shifts myeloid differentiation |
| GSE179360 |
Heme signaling shifts myeloid differentiation in GM-CSF BM cell cultures |
| GSE179362 |
Heme exposure shifts shifts myeloid differentiation in bone marrow derived mixed cell cultures. |
| GSE179363 |
Deviated myeloid differentiation in SCD mice under heme stress I. |
| GSE179364 |
Deviated myeloid differentiation in SCD mice under heme stress II. |
|
| Relations |
| BioProject |
PRJNA743343 |
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