NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE179274 Query DataSets for GSE179274
Status Public on Nov 30, 2021
Title AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice (ribosome profiling)
Organisms Homo sapiens; Mus musculus
Experiment type Other
Summary In this study, we utilized a mouse model of mucopolysaccharidosis type I (MPS-I) carrying a homozygous nonsense mutation in the Idua gene (Idua-W401X, TGG→TAG) to develop rAAV-delivered sup-tRNA therapeutics that can overcome a pathogenic UAG premature termination codon (PTC).
 
Overall design Liver ribosome profilings in sup-tRNA treated and untreated homozygous Idua-W401X mice and patient fibroblasts.
 
Contributor(s) Wang D, Wang J, Zhang Y
Citation(s) 35322228
Submission date Jul 01, 2021
Last update date Apr 22, 2022
Contact name Yue Zhang
E-mail(s) 6leensky@gmail.com
Organization name Umass medical school
Street address GeneTherapyCenter, 368 Plantation st
City Worcester
State/province Massachusetts
ZIP/Postal code 01605
Country USA
 
Platforms (2)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (16)
GSM5412810 Ribo_PFB_Lib1_NT_rep1
GSM5412811 Ribo_PFB_Lib1_NT_rep2
GSM5412812 Ribo_PFB_Lib2_01G418_rep1
This SubSeries is part of SuperSeries:
GSE179275 AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice
Relations
BioProject PRJNA743042
SRA SRP326500

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE179274_Ribo_MsLV_M_countTable.tar.gz 20.8 Mb (ftp)(http) TAR
GSE179274_Ribo_PFB_rep1_countTable.tar.gz 14.9 Mb (ftp)(http) TAR
GSE179274_Ribo_PFB_rep2_countTable.tar.gz 16.6 Mb (ftp)(http) TAR
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap