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Series GSE178973 Query DataSets for GSE178973
Status Public on Oct 06, 2021
Title Moringa oleifera concentrate as a complementary treatment in triple negative breast cancer
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Using a rodent xenograft model of triple negative breast cancer (MDA-MB-231 cells), diet induced obesity, and insulin resistance, the aim of this study is to evaluate the effects of moringa (MC) on improving insulin sensitivity and inhibiting angiogenesis as a dual mechanism by which the efficacy of antineoplastic treatment by standard of care chemotherapy is augmented in vivo.
Overall design B6/Rag1KO were fed a HFD to induce obesity. There was no-treatment lean control group. MDAMB231 cells were injected at 14 weeks of age and 10 weeks on diet. Cells were allowed engraft and tumors grow. After tumors were >200 mm3 on average, tumor bearing mice on the HFD were randomized to one of 4 groups: 1) High Fat Vehicle, 2), High Fat Chemotherapy, 3) High Fat Moringa Concentrate, 4) High Fat Moringa Concentrate Chemotherapy. The lean tumor bearing mice received no intervention.
Contributor(s) Gilmore LA, Newman S, Carmouche R, Kaur J, Zunica ER
Citation(s) 34578801
Submission date Jun 27, 2021
Last update date Oct 06, 2021
Contact name Linda Anne Gilmore
Organization name UT Southwestern Medical Center
Department Clinical Nutrition
Street address 4600 HARRY HINES BLVD
City Dallas
State/province TX
ZIP/Postal code 75390
Country USA
Platforms (1)
GPL19415 Illumina NextSeq 500 (Homo sapiens; Mus musculus)
Samples (24)
GSM5402504 L_03_MC
GSM5402505 L_21_MC
GSM5402506 L_24_MC
BioProject PRJNA741777
SRA SRP325766

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE178973_DES_Normalized_counts_human.txt.gz 3.5 Mb (ftp)(http) TXT
GSE178973_Raw_Counts_human.txt.gz 706.9 Kb (ftp)(http) TXT
GSE178973_mouse_DES_Normalized_counts.txt.gz 3.3 Mb (ftp)(http) TXT
GSE178973_mouse_raw_counts.txt.gz 600.4 Kb (ftp)(http) TXT
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Processed data are available on Series record

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