|
| Status |
Public on Oct 06, 2021 |
| Title |
Moringa oleifera concentrate as a complementary treatment in triple negative breast cancer |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using a rodent xenograft model of triple negative breast cancer (MDA-MB-231 cells), diet induced obesity, and insulin resistance, the aim of this study is to evaluate the effects of moringa (MC) on improving insulin sensitivity and inhibiting angiogenesis as a dual mechanism by which the efficacy of antineoplastic treatment by standard of care chemotherapy is augmented in vivo.
|
| |
|
| Overall design |
B6/Rag1KO were fed a HFD to induce obesity. There was no-treatment lean control group. MDAMB231 cells were injected at 14 weeks of age and 10 weeks on diet. Cells were allowed engraft and tumors grow. After tumors were >200 mm3 on average, tumor bearing mice on the HFD were randomized to one of 4 groups: 1) High Fat Vehicle, 2), High Fat Chemotherapy, 3) High Fat Moringa Concentrate, 4) High Fat Moringa Concentrate Chemotherapy. The lean tumor bearing mice received no intervention.
|
| |
|
| Contributor(s) |
Gilmore LA, Newman S, Carmouche R, Kaur J, Zunica ER |
| Citation(s) |
34578801 |
| Submission date |
Jun 27, 2021 |
| Last update date |
Oct 06, 2021 |
| Contact name |
Linda Anne Gilmore |
| E-mail(s) |
linda.gilmore@utsouthwestern.edu
|
| Organization name |
UT Southwestern Medical Center
|
| Department |
Clinical Nutrition
|
| Street address |
4600 HARRY HINES BLVD
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19415 |
Illumina NextSeq 500 (Homo sapiens; Mus musculus) |
|
| Samples (24)
|
|
| Relations |
| BioProject |
PRJNA741777 |
| SRA |
SRP325766 |
Less...
More...