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GEO accession:
Series GSE176493
Query DataSets for GSE176493
Status
Public on Jun 26, 2024
Title
Comprehensive target engagement by EZH2 inhibitor CPI-0209 allows for preferential targeting of ARID1A mutant urothelial carcinoma
Organism
Homo sapiens
Experiment type
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary
This SuperSeries is composed of the SubSeries listed below.
Overall design
Refer to individual Series
Citation(s)
38833522
Submission date
Jun 09, 2021
Last update date
Jun 29, 2024
Contact name
Patrick Trojer
E-mail(s)
patricktroj@gmail.com
Organization name
Constellation Pharmaceuticals
Street address
215 First Street, Suite 200
City
Cambridge
State/province
Massachusetts
ZIP/Postal code
02142
Country
USA
Platforms (2)
GPL18573
Illumina NextSeq 500 (Homo sapiens)
GPL20301
Illumina HiSeq 4000 (Homo sapiens)
Samples (252)
Less...
More...
GSM5363151
1_EV_DMSO_A
GSM5363152
2_EV_DMSO_B
GSM5363153
3_EV_DMSO_C
GSM5363154
4_EV_DX_DMSO_A
GSM5363155
5_EV_DX_DMSO_B
GSM5363156
6_EV_DX_DMSO_C
GSM5363157
7_EV_0209_A
GSM5363158
8_EV_0209_B
GSM5363159
9_EV_0209_C
GSM5363160
10_EV_DX_0209_A
GSM5363161
11_EV_DX_0209_B
GSM5363162
12_EV_DX_0209_C
GSM5363163
13_A1A_DMSO_A
GSM5363164
14_A1A_DMSO_B
GSM5363165
15_A1A_DMSO_C
GSM5363166
16_A1A_DX_DMSO_A
GSM5363167
17_A1A_DX_DMSO_B
GSM5363168
18_A1A_DX_DMSO_C
GSM5363169
19_A1A_0209_A
GSM5363170
20_A1A_0209_B
GSM5363171
21_A1A_0209_C
GSM5363172
22_A1A_DX_0209_A
GSM5363173
23_A1A_DX_0209_B
GSM5363174
24_A1A_DX_0209_C
GSM5363200
HT1197_DMSO_R1
GSM5363201
HT1197_DMSO_R2
GSM5363202
HT1197_DMSO_R3
GSM5363203
HT1197_CPI-0209_R1
GSM5363204
HT1197_CPI-0209_R2
GSM5363205
HT1197_CPI-0209_R3
GSM5363206
HT1376_DMSO_R1
GSM5363207
HT1376_DMSO_R2
GSM5363208
HT1376_DMSO_R3
GSM5363209
HT1376_CPI-0209_R1
GSM5363210
HT1376_CPI-0209_R2
GSM5363211
HT1376_CPI-0209_R3
GSM5363212
KU1919_DMSO_R1
GSM5363213
KU1919_DMSO_R2
GSM5363214
KU1919_DMSO_R3
GSM5363215
KU1919_CPI-0209_R1
GSM5363216
KU1919_CPI-0209_R2
GSM5363217
KU1919_CPI-0209_R3
GSM5363218
SW780_DMSO_R1
GSM5363219
SW780_DMSO_R2
GSM5363220
SW780_DMSO_R3
GSM5363221
SW780_CPI-0209_R1
GSM5363222
SW780_CPI-0209_R2
GSM5363223
SW780_CPI-0209_R3
GSM5363224
T24_DMSO_R1
GSM5363225
T24_DMSO_R2
GSM5363226
T24_DMSO_R3
GSM5363227
T24_CPI-0209_R1
GSM5363228
T24_CPI-0209_R2
GSM5363229
T24_CPI-0209_R3
GSM5363230
639V_DMSO_R1
GSM5363231
639V_DMSO_R2
GSM5363232
639V_DMSO_R3
GSM5363233
639V_CPI-0209_R1
GSM5363234
639V_CPI-0209_R2
GSM5363235
639V_CPI-0209_R3
GSM5363236
TCCSUP_DMSO_R1
GSM5363237
TCCSUP_DMSO_R2
GSM5363238
TCCSUP_DMSO_R3
GSM5363239
TCCSUP_CPI-0209_R1
GSM5363240
TCCSUP_CPI-0209_R2
GSM5363241
TCCSUP_CPI-0209_R3
GSM5363242
VMCUB_DMSO_R1
GSM5363243
VMCUB_DMSO_R2
GSM5363244
VMCUB_DMSO_R3
GSM5363245
VMCUB_CPI-0209_R1
GSM5363246
VMCUB_CPI-0209_R2
GSM5363247
VMCUB_CPI-0209_R3
GSM5366169
Sample 1: HT1376-TetOn-ARID1A_CPI-0209_with Dox_ARDI1A_R1
GSM5366170
Sample 2: HT1376-TetOn-ARID1A_DMSO_with Dox_ARDI1A_R1
GSM5366171
Sample 3: HT1376-TetOn-ARID1A_CPI-0209_without Dox_ARDI1A_R1
GSM5366172
Sample 4: HT1376-TetOn-ARID1A_DMSO_without Dox_ARDI1A_R1
GSM5366173
Sample 5: HT1376-TetOn_CPI-0209_with Dox_ARDI1A_R1
GSM5366174
Sample 6: HT1376-TetOn_DMSO_with Dox_ARDI1A_R1
GSM5366175
Sample 7: HT1376-TetOn-ARID1A_CPI-0209_with Dox_ARDI1A_R2
GSM5366176
Sample 8: HT1376-TetOn-ARID1A_DMSO_with Dox_ARDI1A_R2
GSM5366177
Sample 9: HT1376-TetOn-ARID1A_CPI-0209_without Dox_ARDI1A_R2
GSM5366178
Sample 10: HT1376-TetOn-ARID1A_DMSO_without Dox_ARDI1A_R2
GSM5366179
Sample 11: HT1376-TetOn_CPI-0209_with Dox_ARDI1A_R2
GSM5366180
Sample 12: HT1376-TetOn_DMSO_with Dox_ARDI1A_R2
GSM5366181
Sample 13: HT1376-TetOn-ARID1A_DMSO_with Dox_SMARCA4_R1
GSM5366182
Sample 14: HT1376-TetOn-ARID1A_DMSO_with Dox_SMARCA4_R1
GSM5366183
Sample 15: HT1376-TetOn-ARID1A_DMSO_without Dox_SMARCA4_R1
GSM5366184
Sample 16: HT1376-TetOn-ARID1A_CPI-0209_without Dox_SMARCA4_R1
GSM5366185
Sample 17: HT1376-TetOn_CPI-0209_with Dox_SMARCA4_R1
GSM5366186
Sample 18: HT1376-TetOn_CPI-0209_with Dox_SMARCA4_R1
GSM5366187
Sample 19: HT1376-TetOn-ARID1A_DMSO_with Dox_SMARCA4_R2
GSM5366188
Sample 20: HT1376-TetOn-ARID1A_DMSO_with Dox_SMARCA4_R2
GSM5366189
Sample 21: HT1376-TetOn-ARID1A_DMSO_without Dox_SMARCA4_R2
GSM5366190
Sample 22: HT1376-TetOn-ARID1A_CPI-0209_without Dox_SMARCA4_R2
GSM5366191
Sample 23: HT1376-TetOn_CPI-0209_with Dox_SMARCA4_R2
GSM5366192
Sample 24: HT1376-TetOn_CPI-0209_with Dox_SMARCA4_R2
GSM5366193
Sample 25: HT1376-TetOn-ARID1A_DMSO_with Dox_H3K27ac_R1
GSM5366194
Sample 26: HT1376-TetOn-ARID1A_DMSO_with Dox_H3K27ac_R1
GSM5366195
Sample 27: HT1376-TetOn-ARID1A_DMSO_without Dox_H3K27ac_R1
GSM5366196
Sample 28: HT1376-TetOn-ARID1A_CPI-0209_without Dox_H3K27ac_R1
GSM5366197
Sample 29: HT1376-TetOn_CPI-0209_with Dox_H3K27ac_R1
GSM5366198
Sample 30: HT1376-TetOn_CPI-0209_with Dox_H3K27ac_R1
GSM5366199
Sample 31: HT1376-TetOn-ARID1A_DMSO_with Dox_H3K27me3_R1
GSM5366200
Sample 32: HT1376-TetOn-ARID1A_DMSO_with Dox_H3K27me3_R1
GSM5366201
Sample 33: HT1376-TetOn-ARID1A_DMSO_without Dox_H3K27me3_R1
GSM5366202
Sample 34: HT1376-TetOn-ARID1A_CPI-0209_without Dox_H3K27me3_R1
GSM5366203
Sample 35: HT1376-TetOn_CPI-0209_with Dox_H3K27me3_R1
GSM5366204
Sample 36: HT1376-TetOn_CPI-0209_with Dox_H3K27me3_R1
GSM5366205
Sample 37: HT1376-TetOn-ARID1A_DMSO_with Dox_H3K4me3_R1
GSM5366206
Sample 38: HT1376-TetOn-ARID1A_DMSO_with Dox_H3K4me3_R1
GSM5366207
Sample 39: HT1376-TetOn-ARID1A_DMSO_without Dox_H3K4me3_R1
GSM5366208
Sample 40: HT1376-TetOn-ARID1A_CPI-0209_without Dox_H3K4me3_R1
GSM5366209
Sample 41: HT1376-TetOn_CPI-0209_with Dox_H3K4me3_R1
GSM5366210
Sample 42: HT1376-TetOn_CPI-0209_with Dox_H3K4me3_R1
GSM5366211
Sample 43: HT1376-TetOn-ARID1A_DMSO_with Dox_IgG_R1
GSM5366212
Sample 44: HT1376-TetOn-ARID1A_DMSO_with Dox_IgG_R1
GSM5366213
Sample 45: HT1376-TetOn-ARID1A_DMSO_without Dox_IgG_R1
GSM5366214
Sample 46: HT1376-TetOn-ARID1A_CPI-0209_without Dox_IgG_R1
GSM5366215
Sample 47: HT1376-TetOn_CPI-0209_with Dox_IgG_R1
GSM5366216
Sample 48: HT1376-TetOn_CPI-0209_with Dox_IgG_R1
GSM5366277
veh_1
GSM5366278
veh_2
GSM5366279
veh_3
GSM5366280
0209_1
GSM5366281
0209_2
GSM5366282
0209_3
GSM5366283
0751_1
GSM5366284
0751_2
GSM5366285
0751_3
GSM5366286
0478_1
GSM5366287
0478_2
GSM5366288
0478_3
GSM5366289
7373_1
GSM5366290
7373_2
GSM5366291
7373_3
GSM5366292
1650_2
GSM5366293
1650_3
GSM5366294
1650_1_resub
GSM5366295
1205_1
GSM5366296
1205_2_resub
GSM5366297
1205_3_resub
GSM5366298
HT1376_DMSO_EZH2
GSM5366299
HT1376_CPI-0209_EZH2
GSM5366300
HT1376_DMSO_H3K27me3
GSM5366301
HT1376_CPI-0209_H3K27me3
GSM5366302
HT1376_DMSO/CPI-0209_Input
GSM5366359
PT1-MT Cycle 1 Day 22
GSM5366360
PT1-MT Cycle 1 Day 1
GSM5366361
PT2-MT Cycle 1 Day 1
GSM5366362
PT2-MT Cycle 1 Day 22
GSM5366363
PT3-MT Cycle 1 Day 1
GSM5366364
PT3-MT Cycle 1 Day 22
GSM5366365
PT4-MT Cycle 1 Day 22
GSM5366366
PT4-MT Cycle 1 Day 1
GSM5366367
PT5-MT Cycle 1 Day 1
GSM5366368
PT5-MT Cycle 1 Day 22
GSM5366369
PT5-MT Cycle 1 Day 15
GSM5366370
PT5-MT Cycle 1 Day 8
GSM5366371
PT5-MT Cycle 3 Day 1
GSM5366372
PT5-MT Cycle 2 Day 1
GSM5366373
PT6-MT Cycle 1 Day 1
GSM5366374
PT6-MT Cycle 1 Day 22
GSM5366375
PT6-MT Cycle 1 Day 15
GSM5366376
PT6-MT Cycle 1 Day 8
GSM5366377
PT6-MT Cycle 2 Day 1
GSM5366378
PT7-MT Cycle 1 Day 1
GSM5366379
PT7-MT Cycle 1 Day 22
GSM5366380
PT8-MT Cycle 1 Day 1
GSM5366381
PT8-MT Cycle 1 Day 22
GSM5366382
PT9-MT Cycle 1 Day 1
GSM5366383
PT9-MT Cycle 1 Day 22
GSM5366384
PT10-MT Cycle 1 Day 1
GSM5366385
PT10-MT Cycle 1 Day 8
GSM5366386
PT10-MT Cycle 1 Day 15
GSM5366387
PT10-MT Cycle 1 Day 22
GSM5366388
PT11-MT Cycle 1 Day 22
GSM5366389
PT11-MT Cycle 1 Day 1
GSM5366390
PT12-MT Cycle 1 Day 1
GSM5366391
PT12-MT Cycle 1 Day 22
GSM5366392
PT12-MT Cycle 1 Day 8
GSM5366393
PT12-MT Cycle 1 Day 15
GSM5366394
PT12-MT Cycle 2 Day 1
GSM5366395
PT13-MT Cycle 1 Day 1
GSM5366396
PT13-MT Cycle 1 Day 22
GSM5366397
PT13-MT Cycle 1 Day 15
GSM5366398
PT13-MT Cycle 1 Day 8
GSM5366399
PT13-MT Cycle 2 Day 1
GSM5366400
PT13-MT Cycle 3 Day 1
GSM5366401
PT14-MT Cycle 1 Day 1
GSM5366402
PT14-MT Cycle 1 Day 22
GSM5366403
PT15-MT Cycle 1 Day 22
GSM5366404
PT15-MT Cycle 1 Day 1
GSM5366405
PT16-MT Cycle 1 Day 1
GSM5366406
PT16-MT Cycle 1 Day 22
GSM5366407
PT17-MT Cycle 1 Day 1
GSM5366408
PT17-MT Cycle 1 Day 22
GSM5366409
PT18-MT Cycle 1 Day 1
GSM5366410
PT18-MT Cycle 1 Day 22
GSM5366411
PT19-MT Cycle 1 Day 22
GSM5366412
PT19-MT Cycle 1 Day 1
GSM5366413
PT20-MT Cycle 1 Day 1
GSM5366414
PT20-MT Cycle 1 Day 22
GSM5366415
PT21-MT Cycle 1 Day 22
GSM5366416
PT21-MT Cycle 1 Day 1
GSM5366417
PT21-MT Cycle 1 Day 8
GSM5366418
PT21-MT Cycle 1 Day 15
GSM5366419
PT21-MT Cycle 2 Day 1
GSM5366420
PT22-MT Cycle 1 Day 1
GSM5366421
PT22-MT Cycle 1 Day 22
GSM5366422
PT22-MT Cycle 1 Day 8
GSM5366423
PT22-MT Cycle 1 Day 15
GSM5366424
PT23-MT Cycle 1 Day 22
GSM5366425
PT23-MT Cycle 1 Day 1
GSM5366426
PT24-MT Cycle 1 Day 8
GSM5366427
PT24-MT Cycle 1 Day 15
GSM5366428
PT24-MT Cycle 1 Day 1
GSM5366429
PT24-MT Cycle 1 Day 22
GSM5366430
PT24-MT Cycle 2 Day 1
GSM5366431
PT24-MT Cycle 3 Day 1
GSM5366432
PT25-MT Cycle 1 Day 22
GSM5366433
PT25-MT Cycle 1 Day 1
GSM5366434
PT25-MT Cycle 2 Day 1
GSM5366435
PT25-MT Cycle 1 Day 15
GSM5366436
PT25-MT Cycle 1 Day 8
GSM5366437
PT26-MT Cycle 1 Day 8
GSM5366438
PT26-MT Cycle 1 Day 15
GSM5366439
PT26-MT Cycle 1 Day 1
GSM5366440
PT26-MT Cycle 1 Day 22
GSM5366441
PT27-MT Cycle 1 Day 22
GSM5366442
PT27-MT Cycle 1 Day 1
GSM5366443
PT28-MT Cycle 1 Day 1
GSM5366444
PT28-MT Cycle 1 Day 22
GSM5366445
PT29-MT Cycle 1 Day 8
GSM5366446
PT29-MT Cycle 1 Day 1
GSM5366447
PT29-MT Cycle 1 Day 15
GSM5366448
PT29-MT Cycle 1 Day 22
GSM5366449
PT29-MT Cycle 2 Day 1
GSM5366450
PT30-MT Cycle 1 Day 1
GSM5366451
PT30-MT Cycle 1 Day 22
GSM5366452
PT30-MT Cycle 1 Day 15
GSM5366453
PT30-MT Cycle 1 Day 8
GSM5366454
PT30-MT Cycle 2 Day 1
GSM5366455
PT31-MT Cycle 1 Day 8
GSM5366456
PT31-MT Cycle 2 Day 1
GSM5366457
PT31-MT Cycle 1 Day 15
GSM5366458
PT31-MT Cycle 1 Day 1
GSM5366459
PT31-MT Cycle 1 Day 22
GSM5366460
PT33-MT Cycle 1 Day 1
GSM5366461
PT33-MT Cycle 1 Day 22
GSM5366462
PT33-MT Cycle 2 Day 1
GSM5366463
PT33-MT Cycle 1 Day 8
GSM5366464
PT33-MT Cycle 1 Day 15
This SuperSeries is composed of the following SubSeries:
Less...
More...
GSE176358
Transcriptomic change of ARDI1A mutant bladder cancer cell line treated with CPI-0209 or induced ARID1A expression
GSE176362
Transcriptomic change of bladder cancer cell lines treated with CPI-0209 [2]
GSE176477
Epigenomic change of ARDI1A mutant bladder cancer cell line treated with CPI-0209 or induced ARID1A expression
GSE176485
Xenograft of bladder cancer cell line HT1376 were treated with or without EZH2 inhibitors before subject to RNA-seq
GSE176486
Epigenomic profile of bladder cancer cell line HT1376 treated with CPI-0209
GSE176490
Study of CPI-0209 in patients with advanced tumors.
Relations
BioProject
PRJNA736424
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Format
SOFT formatted family file(s)
SOFT
MINiML formatted family file(s)
MINiML
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TXT
Supplementary file
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File type/resource
GSE176493_RAW.tar
8.5 Gb
(http)
(custom)
TAR (of BED, BROADPEAK, BW, NARROWPEAK, RESULTS, TXT)
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