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Series GSE176442 Query DataSets for GSE176442
Status Public on Jun 11, 2021
Title Impaired antigen-specific memory B cell and plasma cell responses including lack of specific IgG upon SARS-CoV-2 BNT162b2 vaccination among Kidney Transplant and Dialysis patients
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Single cell transcriptome, cell-surface proterin, TCR and BCR sequencing of FACS-sorted activated T and B cells of the peripheral blood of patients vaccinated against COVID19 after kidney transplant transplantation
Overall design Sequencing of RNA, TCR and BCR was performed from FACS-sorted activated T cells (CD38+ HLA-DR+), memory B cells (CD38low CD27+) and plasmabolasts (CD38high CD27high) from the peripheral blood of four patients vaccinated against COVID19 after kidney transplantation, using the 10X Genomics platform with the Single Cell 5’ Library & Gel Bead Kit
Contributor(s) Schrezenmeier E, Ferreira-Gomes M, Guerra GM, Lehmann K, Heinrich F, Durek P, Mashreghi M
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Submission date Jun 09, 2021
Last update date Jun 13, 2021
Contact name Pawel Durek
Organization name Deutsches Rheuma-Forschungszentrum
Street address Charitéplatz 1
City Berlin
ZIP/Postal code 10117
Country Germany
Platforms (1)
GPL30173 NextSeq 2000 (Homo sapiens)
Samples (4)
GSM5365669 Group4_GEX
GSM5365670 Group4_CITE
GSM5365671 Group4_BCR
BioProject PRJNA736300
SRA SRP323339

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE176442_Group4.filtered_feature_bc_matrix.h5 24.1 Mb (ftp)(http) H5
GSE176442_Group4.filtered_response_annotation.txt.gz 53.7 Kb (ftp)(http) TXT
GSE176442_RAW.tar 2.9 Mb (http)(custom) TAR (of CSV, FASTA)
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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