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Status |
Public on Jun 09, 2021 |
Title |
ATAC-seq analysis of C1qbp sufficient and deficient CD8+ T cells sorted from mice post infection with LCMV Armstrong |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
This study is aimed to explore whether C1qbp deficiency affects the epigenetic modification during the differentiation stage of CD8+ T cells. Transferred WT and C1qbp KO P14 cells sorted from the spleen of donor mice on day 5 post-infection with LCMV Armstrong were collected and treated for ATAC-seq. ATAC-Seq analysis provided sufficient but not necessary evidence of epigenetic changes between WT and C1qbp KO CD8+ T cells. Our study have shown that, on day 5 post-infection with LCMV Armstrong, even WT and C1qbp KO CD8+ T cells have different mRNA expressing profiling, the ATAC-seq shows slight changes in chromatin accessibility of indicated genes.
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Overall design |
ATAC-Seq analysis of transferred WT and C1qbp KO P14 cells sorted from the spleen of donor mice on day 5 post-infection with LCMV Armstrong
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Contributor(s) |
Liu K, Zhai X, Fang H |
Citation(s) |
34860557 |
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Submission date |
Jun 08, 2021 |
Last update date |
Dec 04, 2021 |
Contact name |
liu kai |
E-mail(s) |
21620170155362@stu.xmu.edu.cn
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Phone |
15959281581
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Organization name |
Xiamen University
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Street address |
Xiang'an Campus, Xiamen University, Xiang'an District
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City |
Xiamen |
State/province |
Fujian |
ZIP/Postal code |
361102 |
Country |
China |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (4)
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Relations |
BioProject |
PRJNA736023 |
SRA |
SRP323224 |