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Series GSE176369 Query DataSets for GSE176369
Status Public on Jun 09, 2021
Title ATAC-seq analysis of C1qbp sufficient and deficient CD8+ T cells sorted from mice post infection with LCMV Armstrong
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary This study is aimed to explore whether C1qbp deficiency affects the epigenetic modification during the differentiation stage of CD8+ T cells. Transferred WT and C1qbp KO P14 cells sorted from the spleen of donor mice on day 5 post-infection with LCMV Armstrong were collected and treated for ATAC-seq. ATAC-Seq analysis provided sufficient but not necessary evidence of epigenetic changes between WT and C1qbp KO CD8+ T cells. Our study have shown that, on day 5 post-infection with LCMV Armstrong, even WT and C1qbp KO CD8+ T cells have different mRNA expressing profiling, the ATAC-seq shows slight changes in chromatin accessibility of indicated genes.
 
Overall design ATAC-Seq analysis of transferred WT and C1qbp KO P14 cells sorted from the spleen of donor mice on day 5 post-infection with LCMV Armstrong
 
Contributor(s) Liu K, Zhai X, Fang H
Citation(s) 34860557
Submission date Jun 08, 2021
Last update date Dec 04, 2021
Contact name liu kai
E-mail(s) 21620170155362@stu.xmu.edu.cn
Phone 15959281581
Organization name Xiamen University
Street address Xiang'an Campus, Xiamen University, Xiang'an District
City Xiamen
State/province Fujian
ZIP/Postal code 361102
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM5363337 WT-ATAC rep1
GSM5363338 WT-ATAC rep2
GSM5363339 C1qbp-KO-ATAC rep1
Relations
BioProject PRJNA736023
SRA SRP323224

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE176369_RAW.tar 1.8 Gb (http)(custom) TAR (of BW, NARROWPEAK)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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