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Series GSE174837 Query DataSets for GSE174837
Status Public on May 26, 2021
Title MiRNA expression data of distal colon mucosa from young and old human
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary The disruption of the mucosal barrier of the digestive tract is a common pathological change in the elderly, which often causes inflammatory bowel disease among old people.Given that microRNA (miRNA) molecules are dysregulated in many diseases, the miRNA expression in young and old normal distal colon mucosa in humans was determined by high-throughput analysis. Three young people (27, 28, and 36 years of age) and 3 aged people (72, 79, and 81 years of age) were enrolled in this study. We used microarray analysis to identify miRNA expression in the distal colon mucosa.
 
Overall design A total 6 normal clinical colon mucosa tissue samples from different colorectal cancer patients were collected immediately after surgical resection prior to any other therapeutic intervention. All patients fulfilled the inclusion criteria as follows: (1) Age: young adults 27-36 years old and elderly adults 72-81 years old; (2) All patients were chemotherapy and radiation therapy naïve; (3) The removed normal tissue samples located at descending colon (distal colon). After collection, the samples were stored at -80 °C.
 
Contributor(s) Sun T, Zhou D, Yang S
Citation(s) 34628497
Submission date May 21, 2021
Last update date May 25, 2022
Contact name Tingyi Sun
Organization name Capital Medical University
Street address No.10 Xitoutiao, You'anmenwai, Fengtai District
City Beijing
State/province Beijing
ZIP/Postal code 100069
Country China
 
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (6)
GSM5329047 tissue as young, biological rep1
GSM5329048 tissue as young, biological rep2
GSM5329049 tissue as young, biological rep3
Relations
BioProject PRJNA731871

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE174837_RAW.tar 3.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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