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| Status |
Public on Jan 19, 2022 |
| Title |
FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons [TRAP-seq, RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
We report cell-type and compartment-specific TRAP-seq, RNAseq, FMRP-CLIP, and PAPERCLIP from CA1 hippocampal neurons. We use TRAP-seq and PAPERCLIP data to precisely define the dendritic transcriptome, including mRNAs that harbor APA and AS events that are differentially localized. Further, we use FMRP-CLIP in order to define mRNAs that undergo compartment-specific regulation by FMRP.
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| |
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| Overall design |
Cell-type and compartment-specific TRAP-seq, RNAseq, FMRP-CLIP, and PAPERCLIP from mouse microdissected CA1.
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| |
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| Contributor(s) |
Hale CR, Darnell RB, Carroll T |
| Citation(s) |
34939924 |
| |
| Submission date |
May 12, 2021 |
| Last update date |
Feb 18, 2022 |
| Contact name |
Caryn R Hale |
| E-mail(s) |
chale@rockefeller.edu, carynhale@gmail.com
|
| Organization name |
Rockefeller University
|
| Street address |
1230 York Avenue
|
| City |
New York |
| State/province |
New York |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (48)
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| This SubSeries is part of SuperSeries: |
| GSE180414 |
FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons |
|
| Relations |
| BioProject |
PRJNA729259 |
| SRA |
SRP319412 |
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