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| Status |
Public on Jan 25, 2022 |
| Title |
Transcriptional profiling of dorsal striatum in 1-year-old WT mice and Ash1l heterozygous mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Ash1l encodes a histone methyltransferase, a member of the trithorax group proteins, which regulates developmental essential gene expression by catalyzing H3K36 methylation and counteracting polycomb silencing. Accumulating reports suggest the loss-of-function mutants in Ash1l gene are associated with intellectual disability (ID), attention-deficit/hyperactivity (ADHD), autism spectrum disorder (ASD), Tourette syndrome (TS) and multiple congenital anomalies (MCA). We performed transcriptional profiling of dorsal striatum in 1-year-old Ash1l mutant brain via RNA sequencing (RNA-seq). Ash1l haploinsufficiency induces transcription alternation of genes involved in synaptic function and cortical development, implicating the deficits in synapse pruning and behavior in adult mice.
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| Overall design |
3 WT (1-year-old) and 3 Ash1l heterozygous (1-year-old) dorsal striatum
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| Contributor(s) |
Yan Y, Tian M, Guan J |
| Citation(s) |
35081333 |
| |
| Submission date |
Apr 28, 2021 |
| Last update date |
Jan 27, 2022 |
| Contact name |
Ji-Song Guan |
| E-mail(s) |
guanjs@shanghaitech.edu.cn
|
| Organization name |
ShanghaiTech University
|
| Department |
School of Life Science and Technology
|
| Lab |
Ji-Song Guan lab
|
| Street address |
ShanghaiTech University, Shanghai, China
|
| City |
Shanghai |
| ZIP/Postal code |
201210 |
| Country |
China |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA725848 |
| SRA |
SRP316748 |
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