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Status |
Public on Nov 22, 2022 |
Title |
p63/p73 maintain cancer stem cells in a quasi-mesenchymal state and drive metastatic colonization via EGFR signaling [ATAC-Seq] |
Organism |
Homo sapiens |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
p63/p73 are master transcriptional regulators of ITGB4-hi cancer stem cells and are required to maintain CSCs in a quasi-mesenchymal state and for metastatic colonization
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Overall design |
ATAC-seq of SUM159 ITGB4-hi or SUM159 ITGB4-low cells.
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Contributor(s) |
Lambert A, Fiore C, Wollison B, Guenther M, Weinberg R |
Citation missing |
Has this study been published? Please login to update or notify GEO. |
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Submission date |
Apr 20, 2021 |
Last update date |
Nov 23, 2022 |
Contact name |
Matt Guenther |
Organization name |
Syros Pharmaceuticals
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Street address |
35 Cambridge Park Dr 4th floor
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City |
Cambridge |
State/province |
MA |
ZIP/Postal code |
02140 |
Country |
USA |
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Platforms (1) |
GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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Samples (4)
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This SubSeries is part of SuperSeries: |
GSE172407 |
p63/p73 maintain cancer stem cells in a quasi-mesenchymal state and drive metastatic colonization via EGFR signaling |
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Relations |
BioProject |
PRJNA723261 |
SRA |
SRP315528 |