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Series GSE17156 Query DataSets for GSE17156
Status Public on Aug 06, 2009
Title Gene expression signatures of symptomatic respiratory viral infection in adults
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Diagnosis of acute respiratory viral infection is currentlybased on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis.
We used microarrays to capture peripheral blood gene expression at baseline and time of peak symptoms in healthy volunteers infected intranasally with influenza A H3N2, respiratory syncytial virus or rhinovirus. We determined groups of coexpressed genes that accurately classified symptomatic versus asymptomatic individuals.
Overall design We experimentally inoculated healthy volunteers with intranasal influenza, respiratory syncytial virus or rhinovirus. Symptoms were documented and peripheral blood samples drawn into PAXgene tubes for RNA isolation.
Contributor(s) Ginsburg GS, Carin L
Citation(s) 19664979
Submission date Jul 16, 2009
Last update date Nov 30, 2020
Contact name Geoffrey S Ginsburg
Phone 919-668-6210
Organization name Duke Institute for Genome Sciences & Policy
Department Center for Genomic Medicine
Lab Ginsburg Group
Street address 470 Research Drive, Room 254, box 90141
City Durham
State/province NC
ZIP/Postal code 27708
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (113)
GSM429202 rhinovirus challenge sample at baseline_Rhino001
GSM429203 rhinovirus challenge sample at T_Rhino001
GSM429204 rhinovirus challenge sample at baseline_Rhino002
BioProject PRJNA119759

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17156_RAW.tar 237.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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