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Series GSE170737 Query DataSets for GSE170737
Status Public on Mar 01, 2024
Title Increased homing of immune cells by orexigenic catecholaminergic neurons alleviates autoimmune disorder
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Whole-body energy status significantly impacts the immune system. Both feeding behavior and energy metabolism are controlled by the central nerve system, but it is unknown whether the brain can regulate the immune system in response to fluctuations of the energy status. Here, we show that catecholaminergic (CA) neurons in the nucleus of the solitary tract (NTS) and ventrolateral medulla (VLM) were activated by fasting, and demonstrate that chemogenetic activation of these hindbrain CA neurons both increased food intake and drove homing of CD45+ cells, T cells, and B cells from blood to bone marrow, which was mediated by enhanced HPA axis and upregulation of the chemokine receptor CXCR4. This activation of CA neurons also prevented immune cell infiltration to the brain in the experimental autoimmune encephalomyelitis (EAE) mouse model, and ameliorated the disease outcome. Our study demonstrates the neuronal control of immune function in response to host energy scarcity and sheds light on communications between the nervous and immune systems.
 
Overall design 1. mRNA expression of CD45+ immune cells in the bone marrow of DbhVLM-hM3Dq and DbhVLM-mCherrry mice 4 hour after CNO injections. 2. mRNA expression of CD45+ immune cells in spleen of DbhVLM-hM3Dq and DbhVLM-mCherrry mice 4 hour after CNO injections. . Four biological replicates were prepared for mRNA profiles.
 
Contributor(s) Wang L, Cheng M, Chen J, Feng J, Li Y, Xie F, Huang L, Wang J, Cai T, Zhan C
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Submission date Mar 27, 2021
Last update date Mar 02, 2024
Contact name Liang Wang
E-mail(s) wangliang@ustc.edu.cn
Organization name University of Science and Technology of China
Street address 96 Jinzhai Road
City Hefei
State/province Anhui
ZIP/Postal code 230001
Country China
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (16)
GSM5215317 BM mRNA-Seq DbhVLM-hM3Dq replicate 5
GSM5215318 BM mRNA-Seq DbhVLM-hM3Dq replicate 6
GSM5215319 BM mRNA-Seq DbhVLM-hM3Dq replicate 7
Relations
BioProject PRJNA717968
SRA SRP312424

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE170737_RAW.tar 5.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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