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| Status |
Public on Mar 12, 2024 |
| Title |
Genome-wide methylation profile of uterine cervical carcinoma in Indian patients |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
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| Summary |
Cancer of the uterine cervix (CACX) is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. In India, CACX accounts for approximately 1,22,844 new cases and 67,477 deaths annually. Previously, we catalogued global copy-number aberrations [GSE76911] and performed gene expression profiling [GSE122697] in CACX. Interestingly, differential change in the expression between normal and tumor tissues of several genes did not correlate with the chromosomal copy-number alteration. This encouraged us to perform genome-wide DNA methylation analysis. Hence, in the current study, we discover the global methylation in cervical tumors at different clinical stages and HPV-negative normal ectocervix along with HPV16-positive cervical squamous cell carcinoma cell line, SiHa.
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| Overall design |
Bisulphite converted DNA from the 16 samples (5 normal, and 10 tumor) were hybridised to the Illumina Infinium HumanMethylation850 BeadChip
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| Contributor(s) |
Roychowdhury A, Dutta P, Sammadar S, Maitra A, Roychoudhury S, Kumar Panda C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 12, 2021 |
| Last update date |
Mar 12, 2024 |
| Contact name |
Susanta Roychoudhury |
| E-mail(s) |
anirbanr91@gmail.com
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| Organization name |
Saroj Gupta Cancer Centre & Research Institute
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| Street address |
Mahatma Gandhi Road, Thakurpukur
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| City |
Kolkata |
| State/province |
West Bengal |
| ZIP/Postal code |
700063 |
| Country |
India |
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| Platforms (1) |
| GPL23976 |
Illumina Infinium HumanMethylation850 BeadChip |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA714132 |
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