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Series GSE168813 Query DataSets for GSE168813
Status Public on Mar 13, 2021
Title Inflammatory gene expression profiling in peripheral blood from patients with Alzheimer’s disease reveals key pathways and hub genes with potential diagnostic utility
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Late-onset Alzheimer disease (LOAD) is the most common neurodegenerative disorder worldwide. Recent studies have shown that differential expression in genes (DEG) related to inflammatory response may result associated with disease onset and progression. This study aimed to explore the molecular pathogenesis of LOAD-related inflammation through next-generation sequencing, to assess RNA expression profiles in Alzheimer's disease patients and healthy controls.
Overall design RNA was isolated from whole blood from 5 LOAD cases and 10 controls (all female. Mean age 76.3±3.5). The amplicon sequencing approach using 20812 probes sets specific to human mRNA was applied to assess gene expression profiles, and functional annotation was performed.
Contributor(s) Cardona-Londoño KY, Medina-Salcedo JM, Orrego-Cardozo M, Restrepo de Mejía F, Elcoroaristizabal Martín X, Naranjo-Galvis CA
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Submission date Mar 12, 2021
Last update date Mar 13, 2021
Contact name Antonio Adamo
Organization name King Abdullah University of Science and Technology
Department iological, Environmental Sciences and Engineering
Lab Stem cells and diseases laboratory
Street address Thuwal 23955-6900 KAUST
City Thuwal
State/province Makkah
ZIP/Postal code 23955
Country Saudi Arabia
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (15)
GSM5170642 Healthy control - C1
GSM5170643 Healthy control - C3
GSM5170644 Healthy control - C4
BioProject PRJNA714081
SRA SRP310421

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Supplementary file Size Download File type/resource
GSE168813_Matrix_counts.txt.gz 1.3 Mb (ftp)(http) TXT
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Processed data are available on Series record

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