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Series GSE168656 Query DataSets for GSE168656
Status Public on Apr 01, 2021
Title T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (CUT&RUN)
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We used an integrated genomics approach to profile and characterize the cistrome of TR-beta, map changes in chromatin accessibility, and capture the transcriptomic changes in response to T3 in a normal thyroid cell line. Our data demonstrates that T3 promotes significant shifts in TR-beta genomic occupancy, which are associated with differential chromatin accessibility, and differential recruitment of SWI/SNF chromatin remodelers.
Overall design Epigenetic and transcriptomic anlaysis a of thyroid hormone receptor beta binding and regulation of chormatin accessibility in normal thyroid cells in the presence and absence of thyroid hormone.
Contributor(s) Gillis N, Frietze S, Carr F
Citation(s) 35037038
Submission date Mar 10, 2021
Last update date Mar 04, 2022
Contact name Frances Carr
Organization name University of Vermont
Department Pharmacology
Street address 149 Beaumont Ave, HSRF 340
City Burlington
State/province Vermont
ZIP/Postal code 05405
Country USA
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (17)
GSM5155223 TRb_CUTRUN_vehicle_rep1
GSM5155224 TRb_CUTRUN_vehicle_rep2
GSM5155225 TRb_CUTRUN_T3_rep1
This SubSeries is part of SuperSeries:
GSE168954 T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers
BioProject PRJNA713340
SRA SRP310146

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE168656_ARID1A_T3_IDR.narrowPeak.gz 1.8 Mb (ftp)(http) NARROWPEAK
GSE168656_ARID1A_V_IDR.narrowPeak.gz 2.1 Mb (ftp)(http) NARROWPEAK
GSE168656_BRG1_T3_IDR.narrowPeak.gz 2.4 Mb (ftp)(http) NARROWPEAK
GSE168656_BRG1_V_IDR.narrowPeak.gz 2.8 Mb (ftp)(http) NARROWPEAK
GSE168656_PBRM_T3_IDR.narrowPeak.gz 1.7 Mb (ftp)(http) NARROWPEAK
GSE168656_PBRM_V_IDR.narrowPeak.gz 428.3 Kb (ftp)(http) NARROWPEAK
GSE168656_TRB_T3_IDR.narrowPeak.gz 332.5 Kb (ftp)(http) NARROWPEAK
GSE168656_TRB_V_IDR.narrowPeak.gz 67.6 Kb (ftp)(http) NARROWPEAK
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Raw data are available in SRA
Processed data are available on Series record

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