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Series GSE164934 Query DataSets for GSE164934
Status Public on Jan 16, 2021
Title Ayurvedic herbal preparation supplementation does not improve metabolic health in impaired glucose tolerance subjects; observations from a randomised placebo controlled trial
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The increased usage of alternative Ayurvedic treatments as potential health-beneficial therapies emphasizes the importance of studying its efficacy in sound placebo-controlled intervention trials. An example of such a traditional Ayurvedic herbal preparation is Mohana Choorna, a mixture composed of 20 different herbs and used to prevent and treat type 2-diabetes (T2D). We studied the efficacy of “Mohana Choorna” on T2D-related parameters in subjects with impaired glucose tol-erance. In a double blind, placebo-controlled cross-over trial, 19 overweight (BMI > 27 kg/m2) subjects aged 50–70 years with an impaired glucose tolerance received two four-week interven-tions, i.e., herbal or placebo with a four-week wash-out between interventions. HbA1c, glucose, insulin, triglycerides, cholesterol, blood pressure and augmentation index were measured before and after both interventions at fasting and during a glucose tolerance test. After both interventions, urine was collected to measure treatment exposure using LCMS-based metabolomics and whole genome gene-expression in adipose tissue of 13 subjects. The herbal intervention did not affect plasma glucose triglycerides, cholesterol, blood pressure or the augmentation index but showed a trend towards an increased insulin, HOMA-IR and postprandial insulin levels (p = 0.054, p = 0.056 and p = 0.095 respectively). An increase in expression of inflammation-related gene sets in adipose tissue was observed after the herbal intervention compared to placebo. Urine metabolomic analysis did not reveal a correlation of the presence of specific plant metabolites with “health markers”. Our findings suggest that there is no substantiating evidence to claim that four weeks’ use of the Ayurvedic herbal supplement Mohana Choorna beneficially affects glucose homeo-stasis.
 
Overall design Microarray analysis was performed on subcuteaneous adipose tissue from overweight middle age subjects with an impaired glucose tolerance in cross-over trial with a herbal supplement.
 
Contributor(s) Esser D, Matualatupau J, de Vos R, Wehren R, van der Stappe J, van der Meer I, Afman L
Citation(s) 33477443
Submission date Jan 15, 2021
Last update date Apr 17, 2021
Contact name Guido Hooiveld
E-mail(s) guido.hooiveld@wur.nl
Organization name Wageningen University
Department Div. Human Nutrition & Health
Lab Nutrition, Metabolism & Genomics Group
Street address HELIX, Stippeneng 4
City Wageningen
ZIP/Postal code NL-6708WE
Country Netherlands
 
Platforms (1)
GPL11532 [HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
Samples (26)
GSM5023293 adipose tissue biopsy, after 4 wks supplementation with placebo preparation, subject P02
GSM5023294 adipose tissue biopsy, after 4 wks supplementation with placebo preparation, subject P05
GSM5023295 adipose tissue biopsy, after 4 wks supplementation with placebo preparation, subject P09
Relations
BioProject PRJNA692470

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Supplementary file Size Download File type/resource
GSE164934_RAW.tar 114.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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