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| Status |
Public on Sep 01, 2024 |
| Title |
Transcriptome profiling and Co-expression networks of longissimus dorsi muscle in Gayal（Bos frontalis）and Banna cattle（Bos taurus） with different beef qualities |
| Organisms |
Bos taurus; Bos frontalis |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The Gayal (Bos frontalis) is a rare semi-domesticated cattle in China. Gayal has typical beef body shape and good meat production performance. Compared with other cattle species, it has the characteristics of tender meat and extremely low fat content. To explore the underlying mechanism responsible for the differences of meat quality between different breeds, the longissimus dorsi muscle (LM) from Gayal and Banna cattle (Bos taurus) were investigated using transcriptome analysis. The gene expression profiling identified 638 differentially expressed genes (DEGs) between LM muscles from Gayal and Banna cattle. Gene Ontology (GO) enrichment of biological functions and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the gene products were mainly involved in the PPAR signaling pathway, lipid metabolism and amino acid metabolism pathway. Protein-protein interaction（PPI） network analysis showed APOB, CYP7A1, THBS2, ITGAV, IGFBP1 and IGF2R may have great impact on meat quality characteristics of Gayal. Moreover, three transcription factors, FOXA2, NEUROG2, and RUNX1, which may affect meat quality by regulating the expression of genes related to muscle growth and development have also been found. In summary, our research reveals the molecular mechanisms that cause Gayal meat quality characteristics. It will contribute to improving meat quality of cattle through molecular breeding.
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| Overall design |
The gene expression profiling of the longissimus dorsi muscle (LM) from Gayal and Banna cattle
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| Contributor(s) |
Wang F, Kong X, Xue J, Dong X, Zhu L, Zhang X, Teng H, Jia C, Gou X, Wei Z |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jan 08, 2021 |
| Last update date |
Sep 01, 2024 |
| Contact name |
Zehui Wei |
| E-mail(s) |
weizehui7848@hotmail.com
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| Organization name |
Northwest A&F University
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| Street address |
No.3 Taicheng Road
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| City |
Yangling |
| ZIP/Postal code |
712100 |
| Country |
China |
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| Platforms (2) |
| GPL15749 |
Illumina HiSeq 2000 (Bos taurus) |
| GPL29583 |
Illumina HiSeq 2000 (Bos frontalis) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA690787 |
| SRA |
SRP300904 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE164462_gene_count.csv.gz |
279.6 Kb |
(ftp)(http) |
CSV |
| GSE164462_geuvadis_phenodata.csv.gz |
121 b |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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