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Series GSE16406 Query DataSets for GSE16406
Status Public on Nov 23, 2009
Title Copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary Large but not small copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia: a high-resolution genomic screening of newly diagnosed patients.

Single nucleotide polymorphism (SNP)-arrays allow simultaneous detection of copy-number aberrations (CNAs) and copy-number neutral loss-of-heterozygosity (CNN-LOH). In this study we investigated the presence of CNAs and CNN-LOH in newly diagnosed CLL samples from a Swedish chronic lymphocytic leukemia (CLL) cohort. In this study we could detect the known recurrent aberrations in CLL (i.e. deletions of 13q, 11q, 17p and trisomy 12). We also detected other both large and small CNAs which were mostly non-recurrent. CNN-LOH was detected on chromosome 13q in patients that carried homozygous deletion of 13q.
Overall design In this study, we applied 250K SNP-arrays and screened samples from 203 newly diagnosed chronic lymphocytic leukemia (CLL) patients from a population-based Scandinavian cohort. All samples contained >70% CLL cells.
Citation(s) 19741724
Submission date Jun 03, 2009
Last update date May 17, 2017
Contact name Anders Isaksson
Organization name Uppsala University
Street address Akademiska sjukhuset ing61 3tr
City Uppsala
ZIP/Postal code 75185
Country Sweden
Platforms (1)
GPL3718 [Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array
Samples (203)
GSM412189 SCAN102
GSM412190 SCAN104
GSM412191 SCAN106
BioProject PRJNA116303

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16406_RAW.tar 5.2 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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