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Status |
Public on Mar 07, 2022 |
Title |
The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates with Stimulation of the Host Endoplasmic Reticulum Stress Pathway |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Comparison of cells expressing or not expressing the HCV envelope glycoprotein, E1E2, reveals upregulation of host endoplasmic reticulum stress pathways, including genes such as HSPA5 and ATF3
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Overall design |
Transcritome profiles of HEK293T cells transfected with control plasmid compared with those expressing E1E2 using Oxford Nanopore cDNA sequencing method.
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Contributor(s) |
Paxton WA, Pollakis G, McKay L, Thomas J |
Citation(s) |
35371105 |
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Submission date |
Dec 15, 2020 |
Last update date |
Apr 07, 2022 |
Contact name |
William Anderson Paxton |
E-mail(s) |
wapaxton@liverpool.ac.uk
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Organization name |
University of Liverpool
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Department |
IVES
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Street address |
8 West Derby Street, Ronald Ross Building
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City |
Liverpool |
State/province |
England |
ZIP/Postal code |
L69 7BE |
Country |
United Kingdom |
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Platforms (1) |
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Samples (10)
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Relations |
BioProject |
PRJNA685412 |
SRA |
SRP298008 |