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Series GSE161784 Query DataSets for GSE161784
Status Public on Nov 20, 2020
Title MicroRNA profiling of cisplatin-resistant and cisplatin-sensitive ovarian cancer cells
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Platinum resistance is a major drawback in the treatment of ovarian cancer. Evidence suggests that microRNAs are key players in the initiation, progression, and drug resistance of cancer cells. However, the precise miRNAs dysregulated and contributing to platinum resistance in ovarian cancer cells have not been fully elucidated. Here, we conducted a miRNA expression profiling of cisplatin-sensitive (A2780) and cisplatin-resistant (CP20 and CIS) ovarian cancer cells to identify potential miRNAs involved in platinum resistance.
Overall design Total RNA from ovarian cancer cells was isolated using the mirVana total RNA extraction kit. RNA was biotin-labeled and subjected to Affymetrix GeneChip miRNA 2.0 Arrays.
Contributor(s) PE V
Citation(s) 33392094
Submission date Nov 19, 2020
Last update date Jan 19, 2021
Contact name Pablo E Vivas-Mejía
Organization name University of Puerto Rico Cancer Center
Department Cancer Medicine
Lab Lab 8
Street address Medical Sciences Campus
City San Juan
State/province PR
ZIP/Postal code 00935
Country Puerto Rico
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (6)
GSM4914478 A2780, replicate 1
GSM4914479 A2780, replicate 2
GSM4914480 CIS, replicate 1
BioProject PRJNA679457

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Supplementary file Size Download File type/resource
GSE161784.xls.gz 1.2 Mb (ftp)(http) XLS
GSE161784_RAW.tar 3.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
Processed data are available on Series record

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