GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE16111 Query DataSets for GSE16111
Status Public on Jun 15, 2009
Title BMP4 effect on gene expression program in human primary epidermal keratinocytes and dermal fibroblasts
Organism Homo sapiens
Experiment type Expression profiling by array
Summary BMP signalling is a potent regulator of skin morphogenesis, homeostasis and remodelling. However, molecular mechanisms underlying its involvement in regulating gene expression programs in keratinocytes and fibroblasts remain largely unknown.
We analyzed the effect of BMP4 tratment on gene expression programs in human primary epidermal keratinocyte and dermal fibroblasts cultures. We identified specific changes in gene expression programs for each cell type.
Overall design The primary human epidermal keratinocytes and dermal fibroblasts were treated with recombinant BMP4 or solvent control for 8 hours to reveal early and intermediate response genes. The RNA was isolated and used for micro-array analysis. Changes in gene expression programs were analyzed for each cell type and were compared between cell types.
Contributor(s) Fessing MY, Botchkarev VA
Citation(s) 19710687
Submission date May 14, 2009
Last update date Sep 24, 2019
Contact name Michael Fessing
Organization name University of Bradford
Department Medical Biosciences
Street address Richmond Road
City Bradford
State/province West Yorkshire
ZIP/Postal code BD7 1DP
Country United Kingdom
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (4)
GSM403053 Keratinocytes, control treatment
GSM403054 Keratinocytes, BMP4 treatment
GSM403055 Fibroblasts, control treatment
BioProject PRJNA117225

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16111_RAW.tar 8.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap