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Series GSE161086 Query DataSets for GSE161086
Status Public on Mar 22, 2021
Title IGF2BP1, a conserved regulator of RNA turnover in cancer [polyA RNA]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The IGF2 mRNA binding protein 1 (IGF2BP1) promotes tumor progression in a multitude of solid tumors and its expression is associated with adverse prognosis. The main role proposed for IGF2BP1 in cancer cells is the stabilization of mRNAs encoding pro-oncogenic factors. Several binding studies, however, revealed a plethora of putative IGF2BP1-RNA targets. Thus, at present the main, conserved target RNAs and pathways controlled by IGF2BP1 in cancer remain elusive. In this study, we present a set of genes showing a conserved pattern of deregulation in dependence of IGF2BP1 expression in cancer-derived cell lines. By incorporating publicly available data sets, we further compiled a set of RNAs probably stabilized by IGF2BP1 in cancer and characterized them. Functional enrichment analyses revealed conserved pathways influenced by IGF2BP1 in cancer.
Overall design PolyA RNA-Seq of different solid tumor-derived cells transfected with either control siRNAs (siC) or siRNAs directed against IGF2BP1. Three replicates per condition.
Contributor(s) Glaß M, Misiak D, Bley N, Müller S, Hagemann S, Hüttelmaier S
Citation(s) 33829040
Submission date Nov 09, 2020
Last update date Apr 13, 2021
Contact name Markus Glaß
Organization name Martin Luther University Halle-Wittenberg
Department Institute of Molecular Medicine
Lab Huettelmaier Lab
Street address Kurt-Mothes-Str. 3a
City Halle
ZIP/Postal code 06120
Country Germany
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (12)
GSM4889424 HEPG2_siC_1
GSM4889425 HEPG2_siC_2
GSM4889426 HEPG2_siC_3
This SubSeries is part of SuperSeries:
GSE161101 IGF2BP1, a conserved regulator of RNA turnover in cancer
BioProject PRJNA675511
SRA SRP291708

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Supplementary file Size Download File type/resource
GSE161086_DE_BE2C_C_vs_I1_all.csv.gz 2.3 Mb (ftp)(http) CSV
GSE161086_DE_HEPG2_C_vs_I1_all.csv.gz 2.4 Mb (ftp)(http) CSV
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Processed data are available on Series record

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