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Series GSE161086 Query DataSets for GSE161086
Status Public on Mar 22, 2021
Title IGF2BP1, a conserved regulator of RNA turnover in cancer [polyA RNA]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The IGF2 mRNA binding protein 1 (IGF2BP1) promotes tumor progression in a multitude of solid tumors and its expression is associated with adverse prognosis. The main role proposed for IGF2BP1 in cancer cells is the stabilization of mRNAs encoding pro-oncogenic factors. Several binding studies, however, revealed a plethora of putative IGF2BP1-RNA targets. Thus, at present the main, conserved target RNAs and pathways controlled by IGF2BP1 in cancer remain elusive. In this study, we present a set of genes showing a conserved pattern of deregulation in dependence of IGF2BP1 expression in cancer-derived cell lines. By incorporating publicly available data sets, we further compiled a set of RNAs probably stabilized by IGF2BP1 in cancer and characterized them. Functional enrichment analyses revealed conserved pathways influenced by IGF2BP1 in cancer.
 
Overall design PolyA RNA-Seq of different solid tumor-derived cells transfected with either control siRNAs (siC) or siRNAs directed against IGF2BP1. Three replicates per condition.
 
Contributor(s) Glaß M, Misiak D, Bley N, Müller S, Hagemann S, Hüttelmaier S
Citation(s) 33829040
Submission date Nov 09, 2020
Last update date Apr 13, 2021
Contact name Markus Glaß
E-mail(s) markus.glass@medizin.uni-halle.de
Organization name Martin Luther University Halle-Wittenberg
Department Institute of Molecular Medicine
Lab Huettelmaier Lab
Street address Kurt-Mothes-Str. 3a
City Halle
ZIP/Postal code 06120
Country Germany
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (12)
GSM4889424 HEPG2_siC_1
GSM4889425 HEPG2_siC_2
GSM4889426 HEPG2_siC_3
This SubSeries is part of SuperSeries:
GSE161101 IGF2BP1, a conserved regulator of RNA turnover in cancer
Relations
BioProject PRJNA675511
SRA SRP291708

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE161086_DE_BE2C_C_vs_I1_all.csv.gz 2.3 Mb (ftp)(http) CSV
GSE161086_DE_HEPG2_C_vs_I1_all.csv.gz 2.4 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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