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Series GSE160669 Query DataSets for GSE160669
Status Public on Jul 07, 2022
Title mRNASeq of glioma cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In mouse models of PDGF-driven glioma where Notch is tumor-suppressive, we find that Notch activity shapes interferon-response in tumor cells and the local immune microenvironment early during tumor progression. Notch inhibition disturbs cytokine expression by tumor cells, altering recruitment and activation of immune cell populations and favoring hyper-proliferative "immune niche" independent growth. Genetic inactivation of Notch in glioma cells also attenuates their response to interferon-gamma, establishing a non-cell autonomous inhibitory feedback loop that further promotes immune evasion and aggressiveness. Hence, we propose that Notch signaling levels in tumor cells are key to orchestrate immune escape and microenvironment independency during brain tumor formation.
 
Overall design Expression profiles of PDGF+Trp53-/- glioma cells from tumors with four different Notch mutant genotypes (Rbpj-/-, Notch1-/-Notch2-/-, Notch1-/-, and Notch2-/-) and tumors with intact Notch signaling (PDGF+Trp53-/- control tumors)
 
Contributor(s) Ivanek R, Parmigiani E, Taylor V, Giachino C
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Submission date Nov 02, 2020
Last update date Jul 07, 2022
Contact name DBM Bioinformatics Core Facility
Phone +41612073541
Organization name University of Basel
Department Departement of Biomedicine
Street address Hebelstrasse 20
City Basel
State/province BS
ZIP/Postal code 4053
Country Switzerland
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (26)
GSM4876687 p53__rep1
GSM4876688 p53__rep2
GSM4876689 p53Notch1__rep1
This SubSeries is part of SuperSeries:
GSE160715 Notch activity in tumor cells shapes interferon-gamma response and immune microenvironment in glioma
Relations
BioProject PRJNA673900
SRA SRP290848

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE160669_counts.txt.gz 925.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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