|
| Status |
Public on May 14, 2022 |
| Title |
The MEF2C oncogene opposes Notch signalling in T versus B lineage decision and drives leukemia in the thymus context [ChIP-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Overexpression of the oncogene MEF2C opposes NOTCH signalling in T versus B lineage decision, driving leukemia in the thymus context
|
| |
|
| Overall design |
Binding of transcription factors MEF2C, BRD4, histone modification of Loucy cell line, with overexpression of MEF2C on or of DL1 of with ICN overexpressed.
|
| |
|
| Contributor(s) |
Meijerink JP, Canté-Barrett K, Hagelaar R |
| Citation(s) |
35536646 |
| |
| Submission date |
Oct 29, 2020 |
| Last update date |
May 15, 2022 |
| Contact name |
Rico Hagelaar |
| E-mail(s) |
R.Hagelaar@prinsesmaximacentrum.nl
|
| Organization name |
Princess Maxima Center
|
| Street address |
Heidelberglaan 25
|
| City |
Utrecht |
| ZIP/Postal code |
3584CS |
| Country |
Netherlands |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (12)
|
| GSM4873029 |
Loucy cell line with MEF2C overexpression on DL1 - BRD4 |
| GSM4873030 |
Loucy cell line with MEF2C overexpression on DL1 - H3K27ac |
| GSM4873031 |
Loucy cell line with MEF2C overexpression on DL1 - H3K4me3 |
| GSM4873032 |
Loucy cell line with MEF2C overexpression on DL1 - MEF2C |
| GSM4873033 |
Loucy cell line with MEF2C overexpression on DL1 - input DNA |
| GSM4873034 |
Loucy cell line with MEF2C and ICN overexpression - MEF2C |
| GSM4873035 |
Loucy cell line with MEF2C and ICN overexpression - input DNA |
| GSM4873036 |
Loucy cell line with MEF2C overexpression - BRD4 |
| GSM4873037 |
Loucy cell line with MEF2C overexpression - H3K27ac |
| GSM4873038 |
Loucy cell line with MEF2C overexpression - H3K4me3 |
| GSM4873039 |
Loucy cell line with MEF2C overexpression - MEF2C |
| GSM4873040 |
Loucy cell line with MEF2C overexpression - input DNA |
|
| This SubSeries is part of SuperSeries: |
| GSE160409 |
The MEF2C oncogene opposes Notch signalling in T versus B lineage decision and drives leukemia in the thymus context |
|
| Relations |
| BioProject |
PRJNA673305 |
| SRA |
SRP290289 |
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