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Series GSE158634 Query DataSets for GSE158634
Status Public on Mar 01, 2021
Title Transcriptomic analysis reveals dynamic progression trajectory and molecular pattern of UV-induced cSCC
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In the present study, we aim to identify key genes or pathways in the progression from normal skin to actinic keratoses (AK), then to cutaneous squamous cell carcinoma (cSCC) by transcriptomics analysis. We firstly established a UVR-induced cSCC model using SKH-1 hairless mouse successfully. Then, the transcriptome profiles among normal skin, AK and cSCC were investigated. We also constructed pseudo trajectory and deconvoluted the cell compositions among these three different tissues. A series of bioinformatics and molecular experiments analyses were carried out and we found retinoic acid receptor-related receptor alpha (Rora) was involved in this progression. Our results demonstrated Rora can be a potential therapeutic target for cSCC, which facilitates the treatment of cSCC.
Overall design Examination of mRNA profiles from normal skin, actinic keratoses and cutaneous squamous cell carcinoma tissues
Citation(s) 33664254
Submission date Sep 28, 2020
Last update date Jul 04, 2021
Contact name Sibo Zhu
Phone 13601800295
Organization name Fudan University
Street address songhulu 2005
City Shanghai
State/province China
ZIP/Postal code 200433
Country China
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (20)
GSM4804794 NS_001
GSM4804795 NS_002
GSM4804796 NS_004
BioProject PRJNA666076
SRA SRP285591

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Supplementary file Size Download File type/resource
GSE158634_3.count.csv.gz 527.0 Kb (ftp)(http) CSV
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