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Series GSE157148 Query DataSets for GSE157148
Status Public on Aug 31, 2020
Title Expression of the olfactory receptors OR6X1 and OR4E2 decreases in hypothyroidism and is reversible with levothyroxine treatment in pregnancy
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary These libraries reflect a part of a large study. We construct transcriptome libraries, using whole blood circulating RNAs, of four healthy pregnancy (CTL) and preeclamptic women (PEC). In the manuscript, we perform an edgeR three-group analysis comparing the libraries of healthy thyroid pregnancy (HTP), gestational hypothyroidism (GHT) and preeclampsia (PEC). The HTP and GHT libraries are available in GSE147527. As a result, we obtained 1276 DEG in GHT and 1185 DEG in PEC. We also found 195 olfactory receptors common between only in GHT and PEC.
Overall design We constructed libraries of four healthy pregnancy (CTL) and four preeclamptic women (PEC). The whole blood was collected in the PAXgene Blood RNA tube (QIAGEN, NL, DE) and the RNA was extracted by PAXgene Blood RNA tube (QIAGEN, NL, DE). The sequencing was carried out using an Ion PI Chip (Thermo Fisher Scientific) in an Ion Proton Sequencer (Thermo Fisher Scientific).
Contributor(s) Hirata A, Almeida RJ, Rocha LA, Varela P, Bacigalupo LS, Curi FS, Rodrigues AG, Albejante MC, Silva LM, Silva VA, Pesquero JB, Delle H, Camacho CP
Citation(s) 38069004
Submission date Aug 30, 2020
Last update date Dec 14, 2023
Contact name Robson José de Almeida
Organization name Universidade Nove de Julho
Department Pós Graduação Stricto Sensu em Medicina
Lab Molecular Innovation and Biotechnology Laboratory
Street address RUA VERGUEIRO 235 249
State/province SAO PAULO
ZIP/Postal code 01504-001
Country Brazil
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (8)
GSM4756678 CTL_41
GSM4756679 CTL_42
GSM4756680 CTL_43
BioProject PRJNA660268
SRA SRP279359

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Supplementary file Size Download File type/resource
GSE157148_Matrix_Pregnant_CTL_versus_Pregnant_Pre_Eclampsia.xlsx 1.2 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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