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| Status |
Public on Sep 09, 2020 |
| Title |
Chidamide used in MM primary cells [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Most patients with multiple myeloma (MM) will eventually relapse and current treatments have limited effect. Herein, we demonstrate that succinate dehydrogenase subunitA (SDHA) was low expressed in MM patients, and patients with SDHA relatively high expression had long overall survival and progression-free survival. Furthermore, SDHA high expression inhibited proliferation and invasion in multiple myeloma (MM) cell lines and enhanced the anti-tumor and synergistic effect of chemotherapeutics. We conducted transcriptome comparison of BMMCs of three MM patients treated with DMSO or chidamide.
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| Overall design |
RNA-Seq profiles for BMMCs of three initial MM patients treated with DMSO. RNA-Seq profiles for BMMCs of three initial MM patients treated with chidamide.
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| Contributor(s) |
Sun Y, Xu Z, Xu T, Xu J, Liu P |
| Citation(s) |
33014881 |
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| Submission date |
Aug 19, 2020 |
| Last update date |
Oct 13, 2020 |
| Contact name |
Yifeng Sun |
| E-mail(s) |
16111210013@fudan.edu.cn
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| Organization name |
Zhongshan Hospital, Fudan University
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| Street address |
Fenglin180
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| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (6)
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| GSM4732661 |
patient1, DMSO, BMMCs, CE1706020264LR01 |
| GSM4732662 |
patient1, chidamide, BMMCs, CE1706020265LR01 |
| GSM4732663 |
patient2, DMSO, BMMCs, CE1706020266LR01 |
| GSM4732664 |
patient2, chidamide, BMMCs, CE1706020267LR01 |
| GSM4732665 |
patient3, DMSO, BMMCs, CE1706020268LR01 |
| GSM4732666 |
patient3, chidamide, BMMCs, CE1706020269LR01 |
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA658127 |
| SRA |
SRP278114 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE156501_gene_FPKM_mat.txt.gz |
729.7 Kb |
(ftp)(http) |
TXT |
| GSE156501_gene_count_mat.txt.gz |
652.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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