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Series GSE156181 Query DataSets for GSE156181
Status Public on Dec 31, 2020
Title Receptor Notch-3 - role in kidney fibrosis using an UUO model
Organism Mus musculus
Experiment type Expression profiling by array
Summary Gene array of kidney tissue of wild type and Notch-3 knockout mice was performed following unilateral ureteral obstruction (UUO).
Overall design Kidney fibrosis and inflammation were analyzed following unilateral ureteral obstruction (UUO). UUO was performed with gender matched 12-16 weeks old mice. The right ureters of wild type and Notch3 knockout mice were ligated for 5 days. Both kidneys were collected for preparation of cortical RNA. Contralateral (left untretaed kidney) were harvested for comparative analyses. To gain insight into the mechanism(s) by which Notch3-deficiency alters the pattern of kidney damage, gene expression analysis of UUO kidneys is performed. The expression of fibrosis relevant genes, cytokines&chemokines as well as Notch receptor family members was compared in wild type UUO day 5 samples versus Notch3-/- UUO day 5 samples.
Contributor(s) Brandt S, Geffers R, Mertens PR
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Submission date Aug 13, 2020
Last update date Jan 02, 2021
Contact name Robert Geffers
Phone +49 531-6181-3058
Organization name HCI - Helmholtz Centre for Infection Research
Department Dep. Molecular Bacteriology
Lab Genome Analytics
Street address Inhoffenstr. 7
City Braunschweig
ZIP/Postal code 38124
Country Germany
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (9)
GSM4726164 wild_type_healthy_1
GSM4726165 wild_type_healthy_2
GSM4726166 wild_type_UUO_day_5_1
BioProject PRJNA657003

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE156181_RAW.tar 19.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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