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Series GSE156117 Query DataSets for GSE156117
Status Public on May 15, 2022
Title Analysis of the effect of TSLP stimulated CD4+T cells on epigenetic markers in PyMT primary tumors
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary TSLP-stimulated CD4+ T cells block the promotion of breast cancer in a spontaneous PyMT mouse model. The goal of this project is to investigate what are the epigenetic changes induced by CD4+ T cells that lead to diminished proliferation of cancer cells
Overall design K14-TSLPtg;PyMT;Rag1KO, and PyMT;Rag1KO mice were injected with wt CD4+ T cells at 4 weeks of age. Tumors were collected when they reached terminal size and tissue was processed for ChIP seq analysis.
Contributor(s) Boieri M, Demehri S, Rivera M, Awad M, Iyer S
Citation(s) 35657353
Submission date Aug 12, 2020
Last update date Jun 23, 2022
Contact name Margherita Boieri
Organization name Masachusetts General Hospital
Street address 55 Fruit Street
City Boston
State/province MA
ZIP/Postal code 02114
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (8)
GSM4724984 128651.tumor.H3K27ac
GSM4724985 128651.tumor.INPUT
GSM4724986 209503.tumor.H3K27ac
BioProject PRJNA656800
SRA SRP277218

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE156117_RAW.tar 3.3 Mb (http)(custom) TAR (of BED)
GSE156117_corrected_all_enhancers_up_or_down_2fold_in_tumor_vs_cyst.xlsx 1.4 Mb (ftp)(http) XLSX
GSE156117_emt_genes_higher_in_tumor_vs_cyst.xlsx 14.9 Kb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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