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Status |
Public on May 15, 2022 |
Title |
Analysis of the effect of TSLP stimulated CD4+T cells on epigenetic markers in PyMT primary tumors |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
TSLP-stimulated CD4+ T cells block the promotion of breast cancer in a spontaneous PyMT mouse model. The goal of this project is to investigate what are the epigenetic changes induced by CD4+ T cells that lead to diminished proliferation of cancer cells
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Overall design |
K14-TSLPtg;PyMT;Rag1KO, and PyMT;Rag1KO mice were injected with wt CD4+ T cells at 4 weeks of age. Tumors were collected when they reached terminal size and tissue was processed for ChIP seq analysis.
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Contributor(s) |
Boieri M, Demehri S, Rivera M, Awad M, Iyer S |
Citation(s) |
35657353 |
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Submission date |
Aug 12, 2020 |
Last update date |
Jun 23, 2022 |
Contact name |
Margherita Boieri |
E-mail(s) |
mboieri@mgh.harvard.edu, margherita.boieri@gmail.com
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Organization name |
Masachusetts General Hospital
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Street address |
55 Fruit Street
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City |
Boston |
State/province |
MA |
ZIP/Postal code |
02114 |
Country |
USA |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (8)
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Relations |
BioProject |
PRJNA656800 |
SRA |
SRP277218 |