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Series GSE155643 Query DataSets for GSE155643
Status Public on Aug 03, 2021
Title Pten and Dicer1 loss in the mouse uterus causes poorly-differentiated endometrial adenocarcinoma
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary Endometrial cancer remains the most common gynecological malignancy in the United States. While the loss of the tumor suppressor, PTEN, is well studied in endometrial cancer, recent studies suggest that DICER1, the endoribonuclease responsible for miRNA genesis, also plays a significant role in endometrial adenocarcinoma. To examine the effects of DICER1 deletion on mRNA and miRNA expression in endometrial cancer, poly-A RNA sequencing (RNA-seq) and small RNA sequencing were performed. Our findings indicate a relationship between appropriate miRNA expression and molecular signaling pathways in the development of poorly-differentiated endometrial adenocarcinoma.
 
Overall design Poly-a RNA and small RNA sequencing on mouse uteri and ishikawa cells.
 
Contributor(s) Wang X, Wendel JR, Emerson RE, Broaddus RR, Creighton CJ, Rusch DB, Buechlein A, DeMayo FJ, Lydon JP, Hawkins SM
Citation(s) 32843721
Submission date Aug 03, 2020
Last update date Nov 20, 2021
Contact name Shannon Hawkins
E-mail(s) cgb-geo-hawkins-l@list.indiana.edu
Phone (317) 274-8225
Organization name Indiana University School of Medicine
Street address 340 W. 10th St. FS 6217
City Indianapolis
State/province Indiana
ZIP/Postal code 46202
Country USA
 
Platforms (2)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (36)
GSM4709365 mouse_polyA_2746
GSM4709366 mouse_polyA_3697
GSM4709367 mouse_polyA_3698
Relations
BioProject PRJNA650539
SRA SRP275697

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE155643_humanCounts.polyA.tsv.gz 447.9 Kb (ftp)(http) TSV
GSE155643_human_mirna.counts.tsv.gz 18.0 Kb (ftp)(http) TSV
GSE155643_mouseCounts.polyA.tsv.gz 626.6 Kb (ftp)(http) TSV
GSE155643_mouse_mirna.counts.tsv.gz 20.9 Kb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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