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| Status |
Public on Sep 14, 2021 |
| Title |
Multi-omics profiling of mouse myocardial infarction |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Myocardial infarction (MI), the most severe manifestation of coronary artery disease, is a multifactorial pathophysiologic process. Here, we constructed a MI mouse model through ligation of the proximal left anterior descending coronary artery. Then we detected and analysed multi-omics (transcriptome and proteome) at different time points (Control, 10 mininte, 1 hour, 6 hour, 24 hour and 72 hour) after MI. Immune-related pathway, pyroptosis pathway, and autophagy pathway r were significantly increased after MI.
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| Overall design |
RNA-seq analysis of mouse myocardial infarction at different time points (Control, 10 mininte, 1 hour, 6 hour, 24 hour and 72 hour) after MI.
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| Contributor(s) |
Shen J, Liu W |
| Citation(s) |
34531373, 35346355 |
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| Submission date |
Jun 29, 2020 |
| Last update date |
Apr 06, 2022 |
| Contact name |
Wenju Liu |
| E-mail(s) |
18860929376@163.com
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| Organization name |
University of Tongji
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| Street address |
1239 siping road
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| City |
Shanghai |
| ZIP/Postal code |
200082 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA642848 |
| SRA |
SRP269222 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE153494_All_sample_RPKM.csv.gz |
1.4 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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