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Series GSE152692 Query DataSets for GSE152692
Status Public on Apr 30, 2021
Title Comprehensive single cell RNA-seq datasets of mice trachea epithelial progenitors in 6 time points from E12.5 to E18.5 and mature epithelial cells in 2-month mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We delineate the comprehensive developmental trajectories of trachea epithelial progenitors in mice using scRNA-seq datasets. After obtaining the scRNA-seq data in 6 time points from E12.5 to E18.5, we merged all the datasets to describe the establishment process of basal cell population during development, which works as airway facultative stem cells. We found that Krt17 is a novel intermediate marker for basal cell progenitors and Id genes are key transcriptional factors for balancing the proliferation and differentiation programs by promoting their cell cycle.
Overall design Transcriptomic analyses at single cell resolution of tracheal epithelial cells in 7 time points (E12.5, E13.5, E14.5, E15.5, E16.5, E18.5, and 2 months)
Contributor(s) Kiyokawa H, Morimoto M
Citation(s) 34129836
Submission date Jun 17, 2020
Last update date Jul 30, 2021
Contact name Hirofumi Kiyokawa
Phone 81783063199
Organization name Riken
Department Center for Biosystems Dynamics Research
Lab Laboratory for lung development and regenration
Street address 2-2-3 Minatojima-minamimachi, Chuo-ku
City Kobe
State/province Hyogo
ZIP/Postal code 6500047
Country Japan
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (7)
GSM4623789 Epithelial progenitors E12.5
GSM4623790 Epithelial progenitors E13.5
GSM4623791 Epithelial progenitors E14.5
BioProject PRJNA640145
SRA SRP267715

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE152692_E12-18_Seurat_Processed.Robj.gz 480.3 Mb (ftp)(http) ROBJ
GSE152692_E12-E18_barcodes.tsv.gz 33.7 Kb (ftp)(http) TSV
GSE152692_E12-E18_genes.tsv.gz 212.7 Kb (ftp)(http) TSV
GSE152692_E12-E18_matrix.mtx.gz 64.2 Mb (ftp)(http) MTX
GSE152692_RAW.tar 141.4 Mb (http)(custom) TAR (of MTX, ROBJ, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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