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Series GSE15240 Query DataSets for GSE15240
Status Public on May 26, 2009
Title Gene expression in laboratory models and primary tumors in Small Cell Lung Cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Gene expression was measured on the Affymetrix platform in primary xenografts, xenograft-derived cell lines, secondary xenografts, normal lung, and primary tumors obtained from chemotherapy naive Small Cell Lung Cancer (SCLC). The SCLC primary xenografts were serially propagated in vivo in immunodeficient mice. Cell lines were derived from each xenograft and grown for 6 months using conventional tissue culture conditions. Secondary xenografts were obtained from cell cultures by re-implantation in immunodeficient mice. Such SCLC laboratory models were analyzed along with conventional SCLC cell lines and the derivative secondary xenografts, with normal lung and primary tumors, to assess irreversible gene expression changes induced by culturing conditions.
Overall design SCLC primary xenografts were compared to the corresponding xenograft-derived cell lines, and to the secondary xenografts established from the cell lines using the Affymetrix GeneChip Human Genome U133 Plus 2.0 Array. Gene expression from SCLC primary tumors was measured using the Affymetrix GeneChip Human Genome U133A 2.0 Array. 3 datasets: GSM380476-GSM380512, GSM380513-GSM380516, and GSM380517-GSM380520
Contributor(s) Marchionni L, Watkins ND, Peacock CD, Daniel VC, Hierman JS
Citation(s) 19351829
Submission date Mar 16, 2009
Last update date Mar 25, 2019
Contact name Luigi Marchionni
Phone 410-502-8179
Organization name Johns Hopkins University
Department Oncology
Lab Cancer Biology Program
Street address 1550 Orleans St., CRB2, Room 1M52
City Baltimore
State/province MD
ZIP/Postal code 21231
Country USA
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (45)
GSM380476 Small Cell Lung Cancer Primary xenograft, sample LX33 (X-LX33_Y_A)
GSM380477 Small Cell Lung Cancer cell line H446 (CL-H446_N_A)
GSM380478 Small Cell Lung Cancer cell line H526 (CL-H526_N_A)
BioProject PRJNA116439

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15240_RAW.tar 194.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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