|
| Status |
Public on Nov 24, 2021 |
| Title |
Group-2 Innate Lymphoid Cells Promote Hepatocellular Carcinoma Progression via CXCL2-Neutrophil Induced Immunosuppression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report a tissue-derived KLRG1-ILC2s highly expressing CD69 in HCC, which are distinguished from circulating ones from portal vein and peripheral blood. Relief of KLRG1 inhibitory signaling, the HCC-induced ILC2s tend to shape an immunosuppressive tumor microenvironment through CXCL2/neutrophil axis. Furthermore, the abundance of ILC2s in HCC correlated with the recurrence and progression free survival (PFS) of HCC patients indicated ILC2s being an emerging target for HCC immunotherapy.
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| |
|
| Overall design |
mRNA profiles of ILC2s from HCC and non-tumoral tissues as well as naïve T cells from circulation
|
| |
|
| Contributor(s) |
Xu X, Ye L, Liang T |
| Citation(s) |
33829508 |
| |
| Submission date |
Jun 05, 2020 |
| Last update date |
Nov 24, 2021 |
| Contact name |
Xingyuan Xu |
| E-mail(s) |
21418081@zju.edu.cn
|
| Organization name |
the First Affiliated Hospital, Zhejiang University school of medicine
|
| Street address |
No.79 qingchun road
|
| City |
Hangzhou |
| ZIP/Postal code |
310003 |
| Country |
China |
| |
|
| Platforms (1) |
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| Samples (8)
|
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| Relations |
| BioProject |
PRJNA637600 |
| SRA |
SRP266142 |
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