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Series GSE151792 Query DataSets for GSE151792
Status Public on Sep 15, 2021
Title Transcriptional adaptation to chronic exposure to Cytolethal Distending Toxin in HeLa cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The Cytolethal Distending Toxin (CDT) is a bacterial genotoxin that promotes persistent bacterial colonization during infection and is associated with many inflamatory disorders and cancer. At the cellular level, CDT induces DNA damage and inflammatory signatures in host cells. The aim of this study was to better understand the links betwen CDT-mediated genotoxic activity and immunomodulatory effects. HeLa cells were exposed to a chronic (8 weeks) treatment to 0.25 ng/ml of wild-type (WT) or the catalytic mutant H153A (HA) of CDT from Escherichia coli and transcription analysis was performed using Agilent Sureprint G3 Human GE v2 8x60k microarray.
 
Overall design Human HeLa cells were exposed to 0.25 ng/ml of WT or HA CDT for 8 weeks,then RNAs were extracted.
 
Contributor(s) Vignard J, Hashim S, Naylies C, Lippi Y
Citation(s) 34308492
Submission date Jun 04, 2020
Last update date Sep 16, 2021
Contact name Yannick Lippi
E-mail(s) yannick.lippi@inrae.fr
Organization name INRAE
Department GeT-TRiX facility
Lab TOXALIM UMR1331
Street address 180 chemin de tournefeuille
City Toulouse
ZIP/Postal code 31300
Country France
 
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (15)
GSM4590975 HeLa cell culture - NT - Rep1 [NT_1]
GSM4590976 HeLa cell culture - CDT HA - Rep4 [HA_4]
GSM4590977 HeLa cell culture - CDT WT - Rep1 [CDTR_1]
Relations
BioProject PRJNA637286

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE151792_RAW.tar 184.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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