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Series GSE151725 Query DataSets for GSE151725
Status Public on Jun 04, 2020
Title Genome-wide methylation changes in maternal microchimeric cells from Mmc+ and Mmclow offspring mice
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Summary During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) is largely unknown. We show that MMc induce a preferential differentiation of hematopoietic stem and progenitor cells towards myelopoiesis in bone marrow of fetal mice, and improves resilience against cytomegalovirus infection in neonates. In humans, low MMc counts in cord blood are associated with an increased number of infections in the first year of life primarily in male newborns. Taken together, MMc boost neonatal immunity in mice and humans to mitigate the risk for early life infections.
Overall design Examination of 2 different methylation changes in maternal microchimeric cells.
Contributor(s) Huang J, Ohnezeit D, Fischer N, Stelzer IA, Urbschat C, Arck PC
Citation(s) 34349112
Submission date Jun 03, 2020
Last update date Aug 18, 2021
Contact name Jiabin Huang
Organization name University Medical Center Hamburg-Eppendorf
Street address Martinistr. 52
City Hamburg
ZIP/Postal code 20246
Country Germany
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (12)
GSM4589122 Maternal immune cells – pos_rep2
GSM4589123 Maternal immune cells – pos_rep4
GSM4589124 Maternal immune cells – pos_rep5
BioProject PRJNA637047
SRA SRP265816

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Supplementary file Size Download File type/resource 78.6 Kb (ftp)(http) BED
GSE151725_RAW.tar 359.3 Mb (http)(custom) TAR (of BW)
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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