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Status |
Public on Jun 04, 2020 |
Title |
Genome-wide methylation changes in maternal microchimeric cells from Mmc+ and Mmclow offspring mice |
Organism |
Mus musculus |
Experiment type |
Methylation profiling by high throughput sequencing
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Summary |
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) is largely unknown. We show that MMc induce a preferential differentiation of hematopoietic stem and progenitor cells towards myelopoiesis in bone marrow of fetal mice, and improves resilience against cytomegalovirus infection in neonates. In humans, low MMc counts in cord blood are associated with an increased number of infections in the first year of life primarily in male newborns. Taken together, MMc boost neonatal immunity in mice and humans to mitigate the risk for early life infections.
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Overall design |
Examination of 2 different methylation changes in maternal microchimeric cells.
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Contributor(s) |
Huang J, Ohnezeit D, Fischer N, Stelzer IA, Urbschat C, Arck PC |
Citation(s) |
34349112 |
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Submission date |
Jun 03, 2020 |
Last update date |
Aug 18, 2021 |
Contact name |
Jiabin Huang |
E-mail(s) |
j.huang@uke.de
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Organization name |
University Medical Center Hamburg-Eppendorf
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Street address |
Martinistr. 52
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City |
Hamburg |
ZIP/Postal code |
20246 |
Country |
Germany |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (12)
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GSM4589125 |
Maternal immune cells – neg_rep2 |
GSM4589126 |
Maternal immune cells – neg_rep4 |
GSM4589127 |
Maternal immune cells – neg_rep5 |
GSM4589128 |
Maternal immune cells – pos_rep2 input DNA |
GSM4589129 |
Maternal immune cells – pos_rep4 input DNA |
GSM4589130 |
Maternal immune cells – pos_rep5 input DNA |
GSM4589131 |
Maternal immune cells – neg_rep2 input DNA |
GSM4589132 |
Maternal immune cells – neg_rep4 input DNA |
GSM4589133 |
Maternal immune cells – neg_rep5 input DNA |
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Relations |
BioProject |
PRJNA637047 |
SRA |
SRP265816 |