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| Status |
Public on Jun 04, 2020 |
| Title |
Mapping the effects of developmental lead (Pb) exposure on the hippocampus with single cell analysis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Lead (Pb) exposure is ubiquitous with permanent neurodevelopmental effects. The hippocampus brain region is involved in learning and memory with heterogeneous cellular composition. The hippocampus cell type-specific responses to Pb are unknown. This experiement sought to examine perinatal Pb treatment effects on adult hippocampus gene expression, at the level of individual cells. In mice perinatally exposed to control water or a human physiologically-relevant level (32 ppm in maternal drinking water) of Pb, two weeks prior to mating through weaning, we tested for hippocampus gene expression and cellular differences at 5-months of age.
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| Overall design |
8 mice, 4 perinatally exposed to control diet and 4 to a human physiologically relevant level (32 ppm in maternal drinking water) of lead, two weeks prior to mating through lactation
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| Contributor(s) |
Bakulski KM, Dou JF, Thompson RC, Lee C, Middleton LY, Bambarendage PP, Ferris SP, Jones TR, Neier K, Zhou X, Sartor MA, Hammoud SS, Dolinoy DC, Colacino JA |
| Citation(s) |
32458983 |
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| Submission date |
Jun 03, 2020 |
| Last update date |
Sep 03, 2020 |
| Contact name |
Kelly Bakulski |
| E-mail(s) |
bakulski@umich.edu
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| Organization name |
University of Michigan
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| Department |
Department of Epidemiology
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| Street address |
1415 Washington Heights
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| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA637046 |
| SRA |
SRP265815 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE151723_count_matrix.txt.gz |
13.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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