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Series GSE151454 Query DataSets for GSE151454
Status Public on May 15, 2021
Title The transcriptome of 2 pairs of monozygotic twins clinically discordant for IgA nephropathy
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis involves both genetic and environmental factors. DNA methylation, the most studied epigenetic modification, was shown to play a role in IgAN. In two pairs of IgAN-discordant monozygotic (MZ) twins, here we assessed genome-wide DNA methylation profiling and gene expression profiling in order to characterize DNA methylation changes in IgAN and their potential influences on gene expression.
Overall design Genome-wide DNA methylation and gene expression profiles were evaluated in peripheral blood mononuclear cells (PBMCs) obtained from two MZ twins discordant for IgAN. Differentially methylated regions (DMRs) and differentially expressed genes (DEGs) were detected and an integrated analysis was performed.
Contributor(s) Wei M, Meng S, Shi S, Liu L, Zhou X, Lv J, Zhu L, Zhang H
Citation(s) 34179115
Submission date May 29, 2020
Last update date Aug 15, 2021
Contact name min wei
Phone 18810023542
Organization name perking university First Hospital
Street address No 8, Xishiku Street
City Beijing
ZIP/Postal code 100034
Country China
Platforms (1)
GPL17585 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [probe set (exon) version]
Samples (4)
GSM4578813 PBMCs-HC-Pair2
GSM4578814 PBMCs-IgAN-Pair2
GSM4578815 PBMCs-IgAN-Pair1
This SubSeries is part of SuperSeries:
GSE151457 The transcriptome and genome-wide DNA methylation data of 2 pairs of monozygotic twins clinically discordant for IgA nephropathy
BioProject PRJNA635892

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Supplementary file Size Download File type/resource
GSE151454_RAW.tar 177.3 Mb (http)(custom) TAR (of CEL, CHP, TXT)
Processed data provided as supplementary file

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