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Series GSE151209 Query DataSets for GSE151209
Status Public on May 27, 2020
Title Thyroarytenoid muscle gene expression in Pink1 knockout rats
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary Loss of function in the PTEN-induced kinase 1 gene (Pink1) causes an early-onset, autosomal recessive form of PD. The translational Pink1-/- rat shows cranial sensorimotor deficits including: declines in ultrasonic vocalization, negative impacts on social vocal function, and alterations to thyroarytenoid muscle structure. The aim of this study was to identify differentially expressed genes using RNA-sequencing and bioinformatic analysis of the thyroarytenoid muscle of male Pink1-/- rats compared to wildtype controls. To construct gene co-expression networks and gene modules, a WGCNA was used to identify biological networks of interest including where Pink1 was a central node with interconnecting genes. Data are congruent with previous findings demonstrating changes to thyroarytenoid muscle structure. These data are consistent with the hypothesis that differences in peripheral biology may influence the early pathogenesis of vocalizations at the level of the thyroarytenoid muscle.
Overall design Eight month old Long Evans rats; 8 male (n=4 Pink1-/-, n=4 WT).
Contributor(s) Kelm-Nelson CA, Gammie SC
Citation(s) 36172466
Submission date May 26, 2020
Last update date Oct 24, 2022
Contact name Cynthia A Kelm-Nelson
Phone 4144183662
Organization name University of Wisconsin- Madiso
Department Surgery
Street address 1300 University Avenue, 416 Medical Sciences Center
City Madison
State/province WI
ZIP/Postal code 53706
Country USA
Platforms (1)
GPL14844 Illumina HiSeq 2000 (Rattus norvegicus)
Samples (8)
GSM4568588 S1
GSM4568589 S2
GSM4568590 S3
BioProject PRJNA635128
SRA SRP264815

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Supplementary file Size Download File type/resource
GSE151209_EdgeRglm_GENE_pink1-WT.xlsx 1.6 Mb (ftp)(http) XLSX
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