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| Status |
Public on Jun 15, 2021 |
| Title |
Disruption of Y chromosome expression in male lung cancer: replication |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Lung cancer is the single most frequent cause of cancer death worldwide and is relatively more common in males. For reasons that are currently unknown, lung cancer is also associated with significantly worse outcomes in men than women. Here we replicate clustering of Y-chromosome transcripts identified previously as showing tumor-specific disruption in men with lung cancer.
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| Overall design |
Human whole transcriptome data were generated from pulmonary tumor and, where possible, matched unaffected tissue (referred to hereon as ‘normal’) using the Affymetrix HuGene 1.1 ST microarray, giving a total of 123 samples from 69 patients. Tumor samples and adjacent normal lung tissue were donated from surgical resections, undertaken with curative intent.
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| Contributor(s) |
Arseneault M, Cookson WC, Domingo Sabugo C, Freidin MB, Kiong Lu S, Lathrop M, Liang L, Lim E, Moffatt MF, Nicholson AG, Popat S, Riazalhosseini Y, Starren E, Willis-Owen SA, Zhang Y |
| Citation(s) |
34127738 |
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| Submission date |
May 23, 2020 |
| Last update date |
Nov 16, 2021 |
| Contact name |
William Cookson |
| E-mail(s) |
w.cookson@imperial.ac.uk
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| Organization name |
Imperial College London
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| Street address |
Dovehouse Street
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| City |
London |
| ZIP/Postal code |
SW3 6LY |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL11532 |
[HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (123)
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| GSM4566570 |
Sample n1020 (Lung, Female), Tumor |
| GSM4566571 |
Sample n1031 (Lung, Male), Tumor |
| GSM4566572 |
Sample n1035 (Lung, Female), Tumor |
| GSM4566573 |
Sample n1042 (Lung, Male), Tumor |
| GSM4566574 |
Sample n1049 (Lung, Female), Normal |
| GSM4566575 |
Sample n1049 (Lung, Female), Tumor |
| GSM4566576 |
Sample n1051 (Lung, Female), Normal |
| GSM4566577 |
Sample n1052 (Lung, Female), Normal |
| GSM4566578 |
Sample n1052 (Lung, Female), Tumor |
| GSM4566579 |
Sample n1059 (Lung, Male), Normal |
| GSM4566580 |
Sample n1065 (Lung, Male), Normal |
| GSM4566581 |
Sample n1088 (Lung, Female), Normal |
| GSM4566582 |
Sample n1088 (Lung, Female), Tumor |
| GSM4566583 |
Sample n1089 (Lung, Female), Normal |
| GSM4566584 |
Sample n1089 (Lung, Female), Tumor |
| GSM4566585 |
Sample n1094 (Lung, Male), Normal |
| GSM4566586 |
Sample n1094 (Lung, Male), Tumor |
| GSM4566587 |
Sample n1114 (Lung, Female), Normal |
| GSM4566588 |
Sample n1114 (Lung, Female), Tumor |
| GSM4566589 |
Sample n1119 (Lung, Male), Normal |
| GSM4566590 |
Sample n1119 (Lung, Male), Tumor |
| GSM4566591 |
Sample n1121 (Lung, Male), Normal |
| GSM4566592 |
Sample n1121 (Lung, Male), Tumor |
| GSM4566593 |
Sample n1146 (Lung, Female), Normal |
| GSM4566594 |
Sample n1146 (Lung, Female), Tumor |
| GSM4566595 |
Sample n1163 (Lung, Male), Normal |
| GSM4566596 |
Sample n1167 (Lung, Male), Normal |
| GSM4566597 |
Sample n1167 (Lung, Male), Tumor |
| GSM4566598 |
Sample n1103 (Lung, Male), Normal |
| GSM4566599 |
Sample n1103 (Lung, Male), Tumor |
| GSM4566600 |
Sample n1175 (Lung, Male), Normal |
| GSM4566601 |
Sample n1175 (Lung, Male), Tumor |
| GSM4566602 |
Sample n1177 (Lung, Male), Normal |
| GSM4566603 |
Sample n1179 (Lung, Male), Tumor |
| GSM4566604 |
Sample n1181 (Lung, Female), Normal |
| GSM4566605 |
Sample n1181 (Lung, Female), Tumor |
| GSM4566606 |
Sample n1182 (Lung, Female), Normal |
| GSM4566607 |
Sample n1182 (Lung, Female), Tumor |
| GSM4566608 |
Sample n1184 (Lung, Male), Normal |
| GSM4566609 |
Sample n1186 (Lung, Female), Normal |
| GSM4566610 |
Sample n1186 (Lung, Female), Tumor |
| GSM4566611 |
Sample n1187 (Lung, Male), Normal |
| GSM4566612 |
Sample n1187 (Lung, Male), Tumor |
| GSM4566613 |
Sample n1189 (Lung, Male), Normal |
| GSM4566614 |
Sample n1189 (Lung, Male), Tumor |
| GSM4566615 |
Sample n1196 (Lung, Male), Normal |
| GSM4566616 |
Sample n1196 (Lung, Male), Tumor |
| GSM4566617 |
Sample n1198 (Lung, Female), Normal |
| GSM4566618 |
Sample n1198 (Lung, Female), Tumor |
| GSM4566619 |
Sample n1199 (Lung, Male), Normal |
| GSM4566620 |
Sample n1199 (Lung, Male), Tumor |
| GSM4566621 |
Sample n1200 (Lung, Female), Normal |
| GSM4566622 |
Sample n1200 (Lung, Female), Tumor |
| GSM4566623 |
Sample n1202 (Lung, Female), Normal |
| GSM4566624 |
Sample n1202 (Lung, Female), Tumor |
| GSM4566625 |
Sample n1206 (Lung, Female), Normal |
| GSM4566626 |
Sample n1208 (Lung, Male), Normal |
| GSM4566627 |
Sample n1208 (Lung, Male), Tumor |
| GSM4566628 |
Sample n1209 (Lung, Female), Normal |
| GSM4566629 |
Sample n1209 (Lung, Female), Tumor |
| GSM4566630 |
Sample n1211 (Lung, Female), Normal |
| GSM4566631 |
Sample n1211 (Lung, Female), Tumor |
| GSM4566632 |
Sample n1223 (Lung, Male), Normal |
| GSM4566633 |
Sample n1223 (Lung, Male), Tumor |
| GSM4566634 |
Sample a27805 (Lung, Female), Tumor |
| GSM4566635 |
Sample a27805 (Lung, Female), Normal |
| GSM4566636 |
Sample a29662 (Lung, Male), Normal |
| GSM4566637 |
Sample a29662 (Lung, Male), Tumor |
| GSM4566638 |
Sample a33061 (Lung, Female), Normal |
| GSM4566639 |
Sample a33061 (Lung, Female), Tumor |
| GSM4566640 |
Sample a35329 (Lung, Male), Normal |
| GSM4566641 |
Sample a35267 (Lung, Male), Normal |
| GSM4566642 |
Sample a35267 (Lung, Male), Tumor |
| GSM4566643 |
Sample a37558 (Lung, Female), Tumor |
| GSM4566644 |
Sample a37558 (Lung, Female), Normal |
| GSM4566645 |
Sample a37644 (Lung, Male), Tumor |
| GSM4566646 |
Sample a37644 (Lung, Male), Normal |
| GSM4566647 |
Sample a12047 (Lung, Female), Tumor |
| GSM4566648 |
Sample a12047 (Lung, Female), Normal |
| GSM4566649 |
Sample a34541 (Lung, Female), Tumor |
| GSM4566650 |
Sample a34541 (Lung, Female), Normal |
| GSM4566651 |
Sample a35329 (Lung, Male), Tumor |
| GSM4566652 |
Sample a37668 (Lung, Female), Normal |
| GSM4566653 |
Sample a37668 (Lung, Female), Tumor |
| GSM4566654 |
Sample a37712 (Lung, Male), Normal |
| GSM4566655 |
Sample a37712 (Lung, Male), Tumor |
| GSM4566656 |
Sample a38814 (Lung, Female), Tumor |
| GSM4566657 |
Sample a38814 (Lung, Female), Normal |
| GSM4566658 |
Sample a39605 (Lung, Male), Tumor |
| GSM4566659 |
Sample a39605 (Lung, Male), Normal |
| GSM4566660 |
Sample a40342 (Lung, Female), Tumor |
| GSM4566661 |
Sample a40342 (Lung, Female), Normal |
| GSM4566662 |
Sample a35337 (Lung, Male), Tumor |
| GSM4566663 |
Sample a35365 (Lung, Male), Normal |
| GSM4566664 |
Sample a35365 (Lung, Male), Tumor |
| GSM4566665 |
Sample a37278 (Lung, Male), Tumor |
| GSM4566666 |
Sample a37278 (Lung, Male), Normal |
| GSM4566667 |
Sample a40648 (Lung, Male), Tumor |
| GSM4566668 |
Sample a40648 (Lung, Male), Normal |
| GSM4566669 |
Sample a41136 (Lung, Female), Normal |
| GSM4566670 |
Sample a41136 (Lung, Female), Tumor |
| GSM4566671 |
Sample a41335 (Lung, Female), Tumor |
| GSM4566672 |
Sample a41335 (Lung, Female), Normal |
| GSM4566673 |
Sample a41754 (Lung, Female), Tumor |
| GSM4566674 |
Sample a41754 (Lung, Female), Normal |
| GSM4566675 |
Sample n1163 (Lung, Male), Tumor |
| GSM4566676 |
Sample n1177 (Lung, Male), Tumor |
| GSM4566677 |
Sample a41820 (Lung, Male), Tumor |
| GSM4566678 |
Sample a41820 (Lung, Male), Normal |
| GSM4566679 |
Sample a42761 (Lung, Female), Normal |
| GSM4566680 |
Sample a42761 (Lung, Female), Tumor |
| GSM4566681 |
Sample a42677 (Lung, Female), Normal |
| GSM4566682 |
Sample a42677 (Lung, Female), Tumor |
| GSM4566683 |
Sample a42934 (Lung, Female), Normal |
| GSM4566684 |
Sample a42934 (Lung, Female), Tumor |
| GSM4566685 |
Sample a43567 (Lung, Male), Tumor |
| GSM4566686 |
Sample a43567 (Lung, Male), Normal |
| GSM4566687 |
Sample a43446 (Lung, Male), Tumor |
| GSM4566688 |
Sample a43446 (Lung, Male), Normal |
| GSM4566689 |
Sample a43973 (Lung, Female), Tumor |
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| This SubSeries is part of SuperSeries: |
| GSE151103 |
Disruption of Y chromosome expression in male lung cancer |
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| Relations |
| BioProject |
PRJNA634684 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE151102_RAW.tar |
557.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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