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Series GSE151003 Query DataSets for GSE151003
Status Public on May 21, 2021
Title Effect of caboznatinib on transcriptome and signaling pathways in leukemic cell line K562
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To identify molecular effects of the tyrosine kinase inhibitor cabozantinib (XL184), we applied gene expression profiling in human erythroid leukemic cell lines K562 using Whole Transcriptome Shotgun Sequencing (RNA-seq). After K562 cell were treated with 1uM cabozantinib for 48 h, differentially expressed genes (DEGs) of 241 genes upregulated and 569 were downregulated were found compared with vehicle group. Up-regulated genes enriched in erythroid maturation associated pathways, such as heme metabolism, transcription factor GATA1 targets, and globin synthesis, while those genes downregulated after expose to cabozantinib were enriched in pathways involved in cell proliferation and cell survival function.
 
Overall design Gene expression in K562 was measured after exposure for 48 h to 1uM cabozantinib (XL184) or to the vehicle control (DMSO).
Web link https://www.nature.com/articles/s41417-021-00358-w#citeas
 
Contributor(s) Fu Y, Ou D, Lin L
Citation(s) 34117374
Submission date May 21, 2020
Last update date Aug 20, 2021
Contact name Yu-Hsuan Fu
Organization name National Taiwan University
Department Department of Clinical Laboratory Sciences and Medical Biotechnology
Street address No.1, Chang-Te St
City Taipei
ZIP/Postal code 10048
Country Taiwan
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (2)
GSM4563966 DMSO_48h
GSM4563967 cabozantinib_1uM_48h
Relations
BioProject PRJNA634358
SRA SRP262663

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE151003_20191117_K562_cabo_48.csv.gz 804.6 Kb (ftp)(http) CSV
GSE151003_RAW.tar 3.9 Mb (http)(custom) TAR (of CSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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