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Series GSE150479 Query DataSets for GSE150479
Status Public on Nov 26, 2020
Title Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria.
Organism Mus musculus
Experiment type Expression profiling by array
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Disease tolerance is an important alternative strategy for rapidly acquired immunity to malaria. We show that tolerance is induced by a single malaria episode - in the absence of parasite clearance.
Inflammatory spleen monocytes from C57Bl6/J mice with memory of malaria infection dramatically change their transcriptional response to a second infection; instead of driving emergency inflammation they promote stress and tissue tolerance (RNAseq data available in GEO series GSE150047).
This unique functional profile is not underpinned by alterations in the epigenetic landscape of inflammatory monocytes before their release from the bone marrow (ChIPseq data available in GEO series GSE150478) - tolerance is therefore imprinted within the spleen (microarray data available in GEO series GSE149894).
Hosts thus acquire long-lasting mechanisms that control inflammation (reducing collateral tissue damage) and learn to actively promote stress tolerance (protecting tissues against toxic products and processes) after one malaria episode.

Overall design Refer to individual Series
Citation(s) 33752799
Submission date May 13, 2020
Last update date Mar 29, 2021
Contact name Alasdair Ivens
Phone 44 131 6513605
Organization name Centre for Immunity, Infection and Evolution
Street address Kings Buildings
City Edinburgh
ZIP/Postal code EH9 3FL
Country United Kingdom
Platforms (4)
GPL20258 [MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CDF version]
GPL21103 Illumina HiSeq 4000 (Mus musculus)
GPL21626 NextSeq 550 (Mus musculus)
Samples (91)
GSM4516431 rpm_AJ_1
GSM4516432 rpm_AJ_2
GSM4516433 rpm_AJ_3
This SuperSeries is composed of the following SubSeries:
GSE149894 Tissue printing: splenic red pulp macrophages of once-malaria infected mice are transcriptionally identical to prenatally seeded red pulp macrophages from uninfected mice.
GSE150047 A single malaria episode induces mechanisms that minimise inflammation and promote tolerance in spleen inflammatory monocytes.
GSE150478 Bone marrow monocytes from once-malaria infected mice have no epigenetic memory of the infection.
BioProject PRJNA632548

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Supplementary file Size Download File type/resource
GSE150479_RAW.tar 356.3 Mb (http)(custom) TAR (of CEL, TXT)
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