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Series GSE150073 Query DataSets for GSE150073
Status Public on May 01, 2022
Title Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world’s longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and testes its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, proteome, and epigenome linked to metabolic (dys)regulations. Importantly, dietary intervention partially reversed the metabolic phenotype in Titan mice and significantly extended their life expectancy. Therefore, the Titan mouse line is a valuable resource for translational and interventional obesity research.
 
Overall design RNA Seq experiment of wild-type (non-selected) and Titan (selected for 45 years based on size and weight) in 5 biological replicates
 
Contributor(s) Venkatasubramani AV, Peleg S
Citation(s) 35505192
Submission date May 07, 2020
Last update date May 04, 2022
Contact name Anuroop Venkateswaran Venkatasubramani
E-mail(s) anuroop.venkatasubramani@bmc.med.lmu.de
Phone 01774100976
Organization name Ludwig-Maximilian University of Munich
Department Molecular Biology
Lab Axel Imhof
Street address Großhadernerstr. 9
City Planegg-Martinsried
State/province Bavaria
ZIP/Postal code 82152
Country Germany
 
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (20)
GSM4523019 OldControl_1
GSM4523020 OldControl_2
GSM4523021 OldControl_3
Relations
BioProject PRJNA631036
SRA SRP260486

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE150073_RAW.tar 5.4 Mb (http)(custom) TAR (of TAB)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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