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Series GSE150069 Query DataSets for GSE150069
Status Public on Jun 22, 2020
Title Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline
Organisms Homo sapiens; Mus musculus; Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary Translation of NRF1/NRF2 -mediated liver tissue biomarkers to an in vitro assay using an advanced micropatterned co-culture system (HEPATOPAC®) with primary hepatocytes from male Wistar-Hannover rats or humans
Overall design Rat and human HEPATOPAC® cells and hepatocytes from various sources without treatment and rat and human HEPATOPAC cells dosed repeatedly with pharmaceuticals; total RNA extracted from frozen cells at various time points.
Contributor(s) Podtelezhnikov AA, Kang W, Tanis KQ, Paccione S, Sistare FD
Citation(s) 32559289
Submission date May 07, 2020
Last update date Jun 23, 2020
Contact name Alexei A Podtelezhnikov
Organization name Merck & Co., Inc.
Department Genetics and Pharmacogenomics
Lab WP53B-120
Street address 770 Sumneytown Pike
City West Point
State/province PA
ZIP/Postal code 19486
Country USA
Platforms (7)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
GPL14844 Illumina HiSeq 2000 (Rattus norvegicus)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (240)
GSM4562385 Mouse_liver_C57Bl6_female_untreated_0µM_0hr [TT19-2507_19-0001_L]
GSM4562386 Mouse_liver_C57Bl6_female_untreated_0µM_0hr [TT19-2507_19-0002_L]
GSM4562387 Mouse_liver_C57Bl6_female_untreated_0µM_0hr [TT19-2507_19-0003_L]
BioProject PRJNA634154
SRA SRP262526

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE150069_Human_Hepatopac_Treatments.tar.gz 5.7 Mb (ftp)(http) TAR
GSE150069_Human_Models.tar.gz 9.7 Mb (ftp)(http) TAR
GSE150069_Rat_Hepatopac_Treatments.tar.gz 5.6 Mb (ftp)(http) TAR
GSE150069_Rat_Models.tar.gz 4.3 Mb (ftp)(http) TAR
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Raw data are available in SRA
Processed data are available on Series record

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