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Series GSE149273 Query DataSets for GSE149273
Status Public on Apr 25, 2020
Title RV infections in asthmatics increase ACE2 expression and stimulate cytokine pathways implicated in COVID19
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We present evidence that (1) viral respiratory infections are potential mechanisms of ACE2 overexpression in patients with asthma and (2) ACE activation regulates multiple cytokine anti-viral responses that could explain a mechanism for cytokine surge and associated tissue damage. These results suggest that the recent finding of severe COVID-19 in asthma patients with recent exacerbations may be attributable to synergistic biomolecular interactions with viral co-infections.
Overall design In a paired design experiments across discovery and validation cohorts of in asthmatic patients the biological replicates treated with RVA and RVC were compared to non-treated ones.
Contributor(s) Chang EH, Willis AL, Pouladi N, Li J, Lussier YA
Citation(s) 32649217
Submission date Apr 24, 2020
Last update date Jul 26, 2020
Contact name Eugene H Chang
Phone (520) 626-6673
Organization name The University of Arizona
Department Department of Otolaryngology
Lab Eugene Lab
Street address 1501 N. Campbell Avenue
City Tucson
State/province AZ
ZIP/Postal code 85724
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (90)
GSM4495277 077-Control-1
GSM4495278 077-RVA-1
GSM4495279 077-RVC-1
BioProject PRJNA627860
SRA SRP258285

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Supplementary file Size Download File type/resource
GSE149273_rsem_discovery_validation.txt.gz 4.0 Mb (ftp)(http) TXT
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