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| Status |
Public on Oct 30, 2020 |
| Title |
Single cell characterization of arrested B-lymphoid differentiation and leukemic cell states in ETV6-RUNX1-positive pediatric leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Arrested bone marrow (BM) lymphoid cell differentiation underlies the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). Recurrent genetic lesions often directly involve transcription factors (TFs), such as ETV6 and RUNX1 found in the most common ALL translocation.
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| Overall design |
Here, we studied the effect of ETV6-RUNX1 overexpression in the Nalm-6 cell line model using single cell RNA-seq (scRNA-seq).
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| Contributor(s) |
Mehtonen J, Teppo S, Lahnalampi M, Kokko A, Kaukonen R, Oksa L, Laukkanen S, Bouvy-Liivrand M, Lönnberg T, Lohi O, Heinäniemi M |
| Citation missing |
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| Submission date |
Apr 06, 2020 |
| Last update date |
Oct 30, 2020 |
| Contact name |
Merja Heinäniemi |
| E-mail(s) |
merja.heinaniemi@uef.fi
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| Organization name |
University of Eastern Finland
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| Department |
School of Medicine
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| Street address |
Yliopistonranta 1 E
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| City |
Kuopio |
| ZIP/Postal code |
70211 |
| Country |
Finland |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA623408 |
| SRA |
SRP255480 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE148189_RAW.tar |
51.7 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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