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Series GSE148189 Query DataSets for GSE148189
Status Public on Oct 30, 2020
Title Single cell characterization of arrested B-lymphoid differentiation and leukemic cell states in ETV6-RUNX1-positive pediatric leukemia
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Arrested bone marrow (BM) lymphoid cell differentiation underlies the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). Recurrent genetic lesions often directly involve transcription factors (TFs), such as ETV6 and RUNX1 found in the most common ALL translocation.
Overall design Here, we studied the effect of ETV6-RUNX1 overexpression in the Nalm-6 cell line model using single cell RNA-seq (scRNA-seq).
Contributor(s) Mehtonen J, Teppo S, Lahnalampi M, Kokko A, Kaukonen R, Oksa L, Laukkanen S, Bouvy-Liivrand M, Lönnberg T, Lohi O, Heinäniemi M
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Submission date Apr 06, 2020
Last update date Oct 30, 2020
Contact name Merja Heinäniemi
Organization name University of Eastern Finland
Department School of Medicine
Street address Yliopistonranta 1 E
City Kuopio
ZIP/Postal code 70211
Country Finland
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (2)
GSM4455929 Nalm6_LUC
GSM4455930 Nalm6_ETV6RUNX1
BioProject PRJNA623408
SRA SRP255480

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE148189_RAW.tar 51.7 Mb (http)(custom) TAR (of MTX, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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