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Status |
Public on Apr 01, 2023 |
Title |
Overexpression of the EMT modulator SNAI1 in HPC7 cells |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
Modulators of epithelial to mesenchymal transition (EMT) have recently emerged as novel players in the field of leukemia biology. The mechanisms by which EMT modulators contribute to leukemia pathogenesis, however, remain to be elucidated. Here we investigate the role SNAI1 - a key modulator of EMT – and its effect on chromatin state using ATAC-seq in hematopoietic cells (HPC7).
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Overall design |
A murine hematopoietic progenitor cell line, HPC7, were transduced with a retroviral vector encoding FLAG-tagged SNAI1. Cells were harvested to generate ATAC-seq libraries for Next-Generation Sequencing.
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Contributor(s) |
Carmichael CL, Samuel S, Gillinder K, Mitchell H, Perkins A, Haigh JJ |
Citation missing |
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Submission date |
Apr 01, 2020 |
Last update date |
Apr 01, 2023 |
Contact name |
Kevin Robert Gillinder |
Organization name |
Monash University
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Department |
Australian Centre for Blood Diseases
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Street address |
99 Commercial Road
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City |
Melbourne |
State/province |
Victoria |
ZIP/Postal code |
3004 |
Country |
Australia |
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Platforms (2) |
GPL21626 |
NextSeq 550 (Mus musculus) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (9)
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Relations |
BioProject |
PRJNA622443 |
SRA |
SRP254890 |