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Series GSE147873 Query DataSets for GSE147873
Status Public on Apr 01, 2023
Title Overexpression of the EMT modulator SNAI1 in HPC7 cells
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Modulators of epithelial to mesenchymal transition (EMT) have recently emerged as novel players in the field of leukemia biology. The mechanisms by which EMT modulators contribute to leukemia pathogenesis, however, remain to be elucidated. Here we investigate the role SNAI1 - a key modulator of EMT – and its effect on chromatin state using ATAC-seq in hematopoietic cells (HPC7).
 
Overall design A murine hematopoietic progenitor cell line, HPC7, were transduced with a retroviral vector encoding FLAG-tagged SNAI1. Cells were harvested to generate ATAC-seq libraries for Next-Generation Sequencing.
 
Contributor(s) Carmichael CL, Samuel S, Gillinder K, Mitchell H, Perkins A, Haigh JJ
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Submission date Apr 01, 2020
Last update date Apr 01, 2023
Contact name Kevin Robert Gillinder
Organization name Monash University
Department Australian Centre for Blood Diseases
Street address 99 Commercial Road
City Melbourne
State/province Victoria
ZIP/Postal code 3004
Country Australia
 
Platforms (2)
GPL21626 NextSeq 550 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (9)
GSM4447564 MIG-Snai1, rep1
GSM4447565 MIG-Snai1, rep2
GSM4447566 MIG-Snai1, rep3
Relations
BioProject PRJNA622443
SRA SRP254890

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE147873_Differential_Promoter_Enrichment.csv.gz 210.5 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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