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Series GSE147527 Query DataSets for GSE147527
Status Public on Mar 26, 2020
Title Circulating RNA transcriptome of pregnant women with TSH just above the trimester-specific reference and its correlation with the hypertensive phenotype
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary These libraries are part of a large study to evaluate the impact of thyroid dysfunction in our patients and to compare with health subject. In this part of the study, whole blood circulating RNAs were collected from pregnant women with TSH levels just above the normal range to determine the impact of a mild elevation of TSH in pregnancy. To transcriptome, we selected healthy nonpregnant women (NPG), women with healthy thyroid pregnancy (HTP) and pregnant women with gestational hypothyroidism (GHT). As described in the paper with details, we perform an edgeR three-group analysis. Results have shown that 31.3% of the genes are downregulated and 68.7% are upregulated in HTP.
Overall design We constructed libraries of three women in HTP, three in GHT and three in the NPG group.
Contributor(s) Hirata A, Jesus Rocha LA, Silva VA, Almeida RJ, Bacigalupo LS, Varela P, Silva LM, Pesquero JB, Delle H, Camacho CP
Citation(s) 32296081, 38069004
Submission date Mar 25, 2020
Last update date Dec 14, 2023
Contact name Robson José de Almeida
Organization name Universidade Nove de Julho
Department Pós Graduação Stricto Sensu em Medicina
Lab Molecular Innovation and Biotechnology Laboratory
Street address RUA VERGUEIRO 235 249
State/province SAO PAULO
ZIP/Postal code 01504-001
Country Brazil
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (9)
GSM4432626 NPG1_26
GSM4432627 NPG2_34
GSM4432628 NPG3_32
BioProject PRJNA615181
SRA SRP254024

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE147527_Matrix_NPG_vs_HTP_vs_GHT2020.xlsx 1.3 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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